Neuronal mechanisms mediating pathological reward-related behaviors: a focus on silent synapses in the nucleus accumbens

The compulsive drive to seek drugs despite negative consequences relies heavily on drug-induced alterations that occur within the reward neurocircuit. These alterations include changes in neuromodulator and neurotransmitter systems that ultimately lock behaviors into an inflexible and permanent state. To provide clinicians with improved treatment options, researchers are trying to identify, as potential targets of therapeutic intervention, the neural mechanisms mediating an “addictive-like state”. Here, we discuss how drug-induced generation of silent synapses in the nucleus accumbens may be a potential therapeutic target capable of reversing drug-related behaviors.

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Work Title Neuronal mechanisms mediating pathological reward-related behaviors: a focus on silent synapses in the nucleus accumbens
Access
Open Access
Creators
  1. Dillon McDevitt
  2. Nicholas Graziane
Keyword
  1. Substance abuse
  2. Nucleus accumbens
  3. Silent synapse
  4. Morphine
  5. Cocaine
  6. Drug seeking
License CC BY-NC-ND 4.0 (Attribution-NonCommercial-NoDerivatives)
Work Type Article
Acknowledgments
  1. We thank Dr. Diane McCloskey for proof reading and formatting the article.
Publisher
  1. Pharmacological Research
Publication Date August 29, 2018
Publisher Identifier (DOI)
  1. https://doi.org/10.1016/j.phrs.2018.08.025
Deposited April 03, 2023

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Version 1
published

  • Created
  • Updated
  • Added Creator Nicholas Graziane
  • Added Creator Dillon McDevitt
  • Updated Acknowledgments Show Changes
    Acknowledgments
    • We thank Dr. Diane McCloskey for proof reading and formatting the article.
  • Added 2018-graziane-Pharm research review-12.pdf
  • Updated License Show Changes
    License
    • https://creativecommons.org/licenses/by-nc-nd/4.0/
  • Published
  • Updated Keyword, Publisher, Publisher Identifier (DOI) Show Changes
    Keyword
    • Substance abuse, Nucleus accumbens , Silent synapse, Morphine, Cocaine, Drug seeking
    Publisher
    • Pharmacological Research
    Publisher Identifier (DOI)
    • https://doi.org/10.1016/j.phrs.2018.08.025
  • Updated Creator Nicholas Graziane
  • Updated Creator Dillon McDevitt
  • Updated