Neuronal mechanisms mediating pathological reward-related behaviors: a focus on silent synapses in the nucleus accumbens

Dillon McDevitt; Nicholas Graziane

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Neuronal mechanisms mediating pathological reward-related behaviors: a focus on silent synapses in the nucleus accumbens

The compulsive drive to seek drugs despite negative consequences relies heavily on drug-induced alterations that occur within the reward neurocircuit. These alterations include changes in neuromodulator and neurotransmitter systems that ultimately lock behaviors into an inflexible and permanent state. To provide clinicians with improved treatment options, researchers are trying to identify, as potential targets of therapeutic intervention, the neural mechanisms mediating an “addictive-like state”. Here, we discuss how drug-induced generation of silent synapses in the nucleus accumbens may be a potential therapeutic target capable of reversing drug-related behaviors.

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Metadata

Work Title	Neuronal mechanisms mediating pathological reward-related behaviors: a focus on silent synapses in the nucleus accumbens
Access	Open Access
Creators	Dillon McDevitt Nicholas Graziane
Keyword	Substance abuse Nucleus accumbens Silent synapse Morphine Cocaine Drug seeking
License	CC BY-NC-ND 4.0 (Attribution-NonCommercial-NoDerivatives)
Work Type	Article
Acknowledgments	We thank Dr. Diane McCloskey for proof reading and formatting the article.
Publisher	Pharmacological Research
Publication Date	August 29, 2018
Publisher Identifier (DOI)	https://doi.org/10.1016/j.phrs.2018.08.025
Deposited	April 03, 2023

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Neuronal mechanisms mediating pathological reward-related behaviors: a focus on silent synapses in the nucleus accumbens

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View: 2018-graziane-Pharm research review-12.pdf

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Neuronal mechanisms mediating pathological reward-related behaviors: a focus on silent synapses in the nucleus accumbens

Files

View: 2018-graziane-Pharm research review-12.pdf

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Work History

Version 1 published

Version 1
published