Sonic Hedgehog Pathway Blockade After Surgical Debulk of Large Exophytic Basal Cell Carcinomas

Paul J. Wirth; Ryan Hobbs; Elizabeth Billingsley; Allison T. Vidimos; Charlene Lam

Sonic Hedgehog Pathway Blockade After Surgical Debulk of Large Exophytic Basal Cell Carcinomas

In 2012, the FDA approved vismodegib (Erivedge Genentech, Inc.) for locally advanced basal cell carcinoma (BCC) in addition to other indications. Hedgehog pathway inhibitors have been used as sole therapy as well as adjuvant and neoadjuvant treatment, before definitive surgical management. In the following cases, we describe the utility of surgically debulking large exophytic BCCs before hedgehog pathway inhibitor use to hasten response to the hedgehog inhibitor, decrease duration of therapy, minimize side effects, and potentially decrease recurrence.

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Work Title	Sonic Hedgehog Pathway Blockade After Surgical Debulk of Large Exophytic Basal Cell Carcinomas
Access	Open Access
Creators	Paul J. Wirth Ryan Hobbs Elizabeth Billingsley Allison T. Vidimos Charlene Lam
License	In Copyright (Rights Reserved)
Work Type	Article
Publisher	Dermatologic Surgery
Publication Date	June 7, 2021
Publisher Identifier (DOI)	https://doi.org/10.1097/DSS.0000000000002957
Deposited	March 06, 2023

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Sonic Hedgehog Pathway Blockade After Surgical Debulk of Large Exophytic Basal Cell Carcinomas

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Sonic Hedgehog Pathway Blockade After Surgical Debulk of Large Exophytic Basal Cell Carcinomas

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View: Sonic_Hedgehog_Pathway_Blockade_After_Surgical_Debulk_of_Large_Exophytic_Basal_Cell_Carcinomas.pdf

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Work History

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published