Tuning the Interfacial Properties of Fluorous Colloids Toward Ultrasound Programmable Bioactivity

Atip Lawanprasert; Alda Chau; Janna N. Sloand; Sean Hannifin; Scott H. Medina

Tuning the Interfacial Properties of Fluorous Colloids Toward Ultrasound Programmable Bioactivity

Liquid-in-liquid emulsions are kinetically stable colloids that undergo liquid-to-gas phase transitions in response to thermal or acoustic stimuli. Perfluorocarbons (PFCs) are preferred species as their highly fluorinated nature imparts unique properties that are unparalleled by nonfluorinated counterparts. However, traditional methods to prepare PFC emulsions lack the ability to precisely tune the thermodynamic stability of the fluorous-water interphase and consequently control their vaporization behavior. Here, we report a privileged fluoroalkanoic acid that undergoes concentration-dependent assembly on the surfaces of fluorous droplets to modulate interfacial tension. This allows for the rational formulation of orthogonal PFC droplets that can be programmed to vaporize at specified ultrasound powers. We exploit this behavior in two exemplary biomedical settings by developing emulsions that aid ultrasound-mediated hemostasis and enable bioorthogonal delivery of molecular sensors to mammalian cells. Mechanistic insights gained from these studies can be generalized to tune the thermodynamic interfacial equilibria of PFC emulsions toward designing controllable tools for precision medicine.

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Work Title	Tuning the Interfacial Properties of Fluorous Colloids Toward Ultrasound Programmable Bioactivity
Access	Open Access
Creators	Atip Lawanprasert Alda Chau Janna N. Sloand Sean Hannifin Scott H. Medina
License	In Copyright (Rights Reserved)
Work Type	Article
Publisher	ACS applied materials & interfaces
Publication Date	February 10, 2021
Publisher Identifier (DOI)	https://doi.org/10.1021/acsami.0c20352
Deposited	November 20, 2021

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Tuning the Interfacial Properties of Fluorous Colloids Toward Ultrasound Programmable Bioactivity

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View: PFNA_Emulsion_-_Manuscript_Revised.docx

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Tuning the Interfacial Properties of Fluorous Colloids Toward Ultrasound Programmable Bioactivity

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View: PFNA_Emulsion_-_Manuscript_Revised.docx

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Work History

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