Benralizumab as an Adjuvant Therapy for Recurrent Laryngeal Papillomatosis

Recurrent respiratory (RRP) or laryngeal papillomatosis is the result of human papillomavirus-mediated benign tumor growth on the larynx and is challenging to manage. Benralizumab is a monoclonal antibody targeted against the alpha subunit of the IL-5 receptor on eosinophils. A 61-year-old male patient presented with refractory RRP following multiple surgical excisions. His disease course improved substantially when benralizumab was added to his asthma regimen. There is no clear mechanistic role suggested for benralizumab directly treating RRP. This case may represent a novel application of benralizumab as an adjuvant treatment for patients with RRP and comorbid asthma. Laryngoscope, 2022.

This is the peer reviewed version of the following article: [Benralizumab as an Adjuvant Therapy for Recurrent Laryngeal Papillomatosis. The Laryngoscope 133, 4 p863-865 (2022)], which has been published in final form at https://doi.org/10.1002/lary.30527. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions: https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/self-archiving.html#3.