Timing of peripubertal steroid exposure predicts visuospatial cognition in men: Evidence from three samples

Experiments in male rodents demonstrate that sensitivity to the organizational effects of steroid hormones decreases across the pubertal window, with earlier androgen exposure leading to greater masculinization of the brain and behavior. Similarly, some research suggests the timing of peripubertal exposure to sex steroids influences aspects of human psychology, including visuospatial cognition. However, prior studies have been limited by small samples and/or imprecise measures of pubertal timing. We conducted 4 studies to clarify whether the timing of peripubertal hormone exposure predicts performance on male-typed tests of spatial cognition in adulthood. In Studies 1 (n = 1095) and 2 (n = 173), we investigated associations between recalled pubertal age and spatial cognition in typically developing men, controlling for current testosterone levels in Study 2. In Study 3 (n = 51), we examined the relationship between spatial performance and the age at which peripubertal hormone replacement therapy was initiated in a sample of men with Isolated GnRH Deficiency. Across Studies 1–3, effect size estimates for the relationship between spatial performance and pubertal timing ranged from. −0.04 and −0.27, and spatial performance was unrelated to salivary testosterone in Study 2. In Study 4, we conducted two meta-analyses of Studies 1–3 and four previously published studies. The first meta-analysis was conducted on correlations between spatial performance and measures of the absolute age of pubertal timing, and the second replaced those correlations with correlations between spatial performance and measures of relative pubertal timing where available. Point estimates for correlations between pubertal timing and spatial cognition were −0.15 and −0.12 (both p < 0.001) in the first and second meta-analyses, respectively. These associations were robust to the exclusion of any individual study. Our results suggest that, for some aspects of neural development, sensitivity to gonadal hormones declines across puberty, with earlier pubertal hormone exposure predicting greater sex-typicality in psychological phenotypes in adulthood. These results shed light on the processes of behavioral and brain organization and have implications for the treatment of IGD and other conditions wherein pubertal timing is pharmacologically manipulated.

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Work Title Timing of peripubertal steroid exposure predicts visuospatial cognition in men: Evidence from three samples
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Open Access
Creators
  1. Talia N. Shirazi
  2. Heather Self
  3. James Cantor
  4. Khytam Dawood
  5. Rodrigo Cárdenas
  6. Kevin Rosenfield
  7. Triana Ortiz
  8. Justin Carré
  9. Michael A. McDaniel
  10. Ray Blanchard
  11. Ravikumar Balasubramanian
  12. Angela Delaney
  13. William Crowley
  14. S. Marc Breedlove
  15. David Puts
License In Copyright (Rights Reserved)
Work Type Article
Publisher
  1. Hormones and Behavior
Publication Date May 1, 2020
Publisher Identifier (DOI)
  1. https://doi.org/10.1016/j.yhbeh.2020.104712
Deposited November 16, 2021

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Version 1
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  • Created
  • Added Shirazi_et_al_2020b_Horm_Behav_accepted.pdf
  • Added Creator Talia N. Shirazi
  • Added Creator Heather Self
  • Added Creator James Cantor
  • Added Creator Khytam Dawood
  • Added Creator Rodrigo Cárdenas
  • Added Creator Kevin Rosenfield
  • Added Creator Triana Ortiz
  • Added Creator Justin Carré
  • Added Creator Michael A. McDaniel
  • Added Creator Ray Blanchard
  • Added Creator Ravikumar Balasubramanian
  • Added Creator Angela Delaney
  • Added Creator William Crowley
  • Added Creator S. Marc Breedlove
  • Added Creator David Puts
  • Published
  • Updated
  • Updated