Depth filtration in bioprocessing — new opportunities for an old technology

Depth filtration has a long history in both bioprocessing and water treatment, with the earliest records of water purification by depth filtration dating back 4000 years. The renewed interest in depth filtration for bioprocessing has been driven by the push towards single-use manufacturing technologies along with the increased turbidity arising from improvements in cell density and product titer. This review highlights the key principles, developments, and applications of depth filtration systems, including growing opportunities for use of depth filtration for both initial clarification and for treatment of in-process streams to reduce host cell proteins and remove key foulants to improve the overall performance of the downstream process.

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Work Title Depth filtration in bioprocessing — new opportunities for an old technology
Access
Open Access
Creators
  1. Negin Nejatishahidein
  2. Andrew Zydney
Keyword
  1. Depth filtration
  2. Bioprocessing
  3. Clarification
  4. Filtration
  5. Biomanufacturing
License CC BY-NC-ND 4.0 (Attribution-NonCommercial-NoDerivatives)
Work Type Article
Publisher
  1. Current Opinion in Chemical Engineering
Publication Date December 1, 2021
Publisher Identifier (DOI)
  1. https://doi.org/10.1016/j.coche.2021.100746
Deposited July 21, 2022

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Version 1
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  • Created
  • Added Depth_filtration_in_bioprocessing-unmarked.docx
  • Added Creator Negin Nejatishahidein
  • Added Creator Andrew Zydney
  • Published
  • Updated Work Title, Keyword, Description Show Changes
    Work Title
    • Depth filtration in bioprocessing — new opportunities for an old technology
    • ! Depth filtration in bioprocessing — new opportunities for an old technology
    Keyword
    • Depth filtration, Bioprocessing, Clarification, Filtration, Biomanufacturing
    Description
    • Depth filtration has a long history in both bioprocessing and water treatment, with the earliest records of water purification by depth filtration dating back 4000 years. The renewed interest in depth filtration for bioprocessing has been driven by the push towards single-use manufacturing technologies along with the increased turbidity arising from improvements in cell density and product titer. This review highlights the key principles, developments, and applications of depth filtration systems, including growing opportunities for use of depth filtration for both initial clarification and for treatment of in-process streams to reduce host cell proteins and remove key foulants to improve the overall performance of the downstream process.
    • Depth filtration has a long history in both bioprocessing and water treatment, with the earliest records of water purification by depth filtration dating back 4000 years. The renewed interest in depth filtration for bioprocessing has been driven by the push towards single-use manufacturing technologies along with the increased turbidity arising from improvements in cell density and product titer. This review highlights the key principles, developments, and applications of depth filtration systems, including growing opportunities for use of depth filtration for both initial clarification and for treatment of in-process streams to reduce host cell proteins and remove key foulants to improve the overall performance of the downstream process.
  • Updated Work Title Show Changes
    Work Title
    • ! Depth filtration in bioprocessing — new opportunities for an old technology
    • Depth filtration in bioprocessing — new opportunities for an old technology
  • Updated