Insomnia with Objective Short Sleep Duration in Women with Temporomandibular Joint Disorder: Quantitative Sensory Testing, Inflammation and Clinical Pain Profiles

Objectives/background: Temporomandibular joint disorder (TMD) is a disabling facial pain syndrome with a high prevalence of insomnia that primarily affects women. Insomnia with objective short sleep duration (ISSD) is an emerging phenotype linked to cardiometabolic morbidity and increased mortality. The present report examines the association of ISSD on clinical and laboratory pain and systemic inflammation in TMD.

Methods: We collected baseline data from 128 women with TMD and insomnia as part of a clinical trial evaluating psychological interventions for sleep and pain. Participants completed self-report questionnaires, one-night polysomnography, a two-week actigraphy assessment, quantitative sensory testing (QST) to assess cold pain tolerance, pain sensitivity and central sensitization and circulating Interleukin-6 levels were measured to assess systemic inflammation.

Results: 24.2% (n = 31) of the sample met criteria for ISSD [polysomnography (sleep duration <6 h)]. Compared to those with insomnia and normal sleep duration, ISSD were older (40.4 vs. 34.9,p < 0.05) and a greater proportion self-identified as Black (48.4% vs 11.3%,p < 0.001). Multivariate regressions revealed that ISSD endorsed higher self-report pain severity and functional limitation of the jaw. ISSD also demonstrated increased generalized pain sensitivity, enhanced central sensitization, cold pressor tolerance and higher resting interleukin-6 levels.

Conclusions: This is the first study to characterize the ISSD phenotype in a chronic pain sample and expand the scope of its negative health outcomes to chronic pain. ISSD may be an important chronic pain phenotype associated with a more severe clinical and laboratory pain profile, and future studies should focus on implications for treatment response and disease trajectory.

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Work Title Insomnia with Objective Short Sleep Duration in Women with Temporomandibular Joint Disorder: Quantitative Sensory Testing, Inflammation and Clinical Pain Profiles
Access
Open Access
Creators
  1. Sheera F. Lerman
  2. Chung Jung Mun
  3. Carly A. Hunt
  4. Shriya Kunatharaju
  5. Luis F. Buenaver
  6. Patrick H. Finan
  7. Claudia M. Campbell
  8. Jane Phillips
  9. Julio Fernandez-Mendoza
  10. Jennifer A. Haythornthwaite
  11. Michael T. Smith
Keyword
  1. Insomnia
  2. objective sleep duration
  3. phenotypes
  4. chronic pain
  5. temporomandibular disorder
  6. quantitative sensory testing
  7. inflammation
  8. Central sensitization
  9. pain tolerance
License In Copyright (Rights Reserved)
Work Type Article
Publisher
  1. Sleep Medicine
Publication Date January 8, 2022
Publisher Identifier (DOI)
  1. https://doi.org/10.1016/j.sleep.2022.01.004
Deposited July 26, 2022

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Version 1
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  • Created
  • Added Manuscript_R1_Clean.docx
  • Added Creator S F Lerman
  • Added Creator C J Mun
  • Added Creator C A Hunt
  • Added Creator S Kunatharaju
  • Added Creator Luis F Buenaver
  • Added Creator P H Finan
  • Added Creator C M Campbell
  • Added Creator J Phillips
  • Added Creator Julio Fernandez-Mendoza
  • Added Creator J A Haythornthwaite
  • Added Creator Michael T Smith
  • Published
  • Updated Work Title, Keyword Show Changes
    Work Title
    • Insomnia with Objective Short Sleep Duration in Women with Temporomandibular Joint Disorder: Quantitative Sensory Testing, Inflammation and Clinical Pain Profiles
    • ! Insomnia with Objective Short Sleep Duration in Women with Temporomandibular Joint Disorder: Quantitative Sensory Testing, Inflammation and Clinical Pain Profiles
    Keyword
    • Insomnia, objective sleep duration, phenotypes, chronic pain, temporomandibular disorder, quantitative sensory testing, inflammation, Central sensitization, pain tolerance
  • Renamed Creator Sheera F. Lerman Show Changes
    • S F Lerman
    • Sheera F. Lerman
  • Renamed Creator Chung Jung Mun Show Changes
    • C J Mun
    • Chung Jung Mun
  • Renamed Creator Carly A. Hunt Show Changes
    • C A Hunt
    • Carly A. Hunt
  • Renamed Creator Shriya Kunatharaju Show Changes
    • S Kunatharaju
    • Shriya Kunatharaju
  • Renamed Creator Luis F. Buenaver Show Changes
    • Luis F Buenaver
    • Luis F. Buenaver
  • Renamed Creator Patrick H. Finan Show Changes
    • P H Finan
    • Patrick H. Finan
  • Renamed Creator Claudia M. Campbell Show Changes
    • C M Campbell
    • Claudia M. Campbell
  • Renamed Creator Jane Phillips Show Changes
    • J Phillips
    • Jane Phillips
  • Renamed Creator Jennifer A. Haythornthwaite Show Changes
    • J A Haythornthwaite
    • Jennifer A. Haythornthwaite
  • Renamed Creator Michael T. Smith Show Changes
    • Michael T Smith
    • Michael T. Smith
  • Updated Work Title Show Changes
    Work Title
    • ! Insomnia with Objective Short Sleep Duration in Women with Temporomandibular Joint Disorder: Quantitative Sensory Testing, Inflammation and Clinical Pain Profiles
    • Insomnia with Objective Short Sleep Duration in Women with Temporomandibular Joint Disorder: Quantitative Sensory Testing, Inflammation and Clinical Pain Profiles
  • Updated