Changes in functional connectivity related to direct training and generalization effects of a word finding treatment in chronic aphasia

The neural mechanisms that underlie generalization of treatment-induced improvements in word finding in persons with aphasia (PWA) are currently poorly understood. This study aimed to shed light on changes in functional network connectivity underlying generalization in aphasia. To this end, we used fMRI and graph theoretic analyses to examine changes in functional connectivity after a theoretically-based word-finding treatment in which abstract words were used as training items with the goal of promoting generalization to concrete words. Ten right-handed native English-speaking PWA (7 male, 3 female) ranging in age from 47 to 75 (mean = 59) participated in this study. Direct training effects coincided with increased functional connectivity for regions involved in abstract word processing. Generalization effects coincided with increased functional connectivity for regions involved in concrete word processing. Importantly, similarities between training and generalization effects were noted as were differences between participants who generalized and those who did not.

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Work Title Changes in functional connectivity related to direct training and generalization effects of a word finding treatment in chronic aphasia
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Open Access
Creators
  1. Chaleece Sandberg (she/her)
  2. Jason w. Bohland
  3. Swathi Kiran
Keyword
  1. aphasia
  2. treatment
  3. fMRI
  4. functional connectivity
  5. generalization
  6. neuroplasticity
License CC BY-NC-ND 4.0 (Attribution-NonCommercial-NoDerivatives)
Work Type Article
Publisher
  1. Brain and Language
Publication Date November 2015
Publisher Identifier (DOI)
  1. http://dx.doi.org/10.1016/j.bandl.2015.09.002
Deposited October 01, 2024

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Version 1
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  • Created
  • Updated
  • Updated
  • Updated Keyword, Publisher Identifier (DOI), Description, and 1 more Show Changes
    Keyword
    • aphasia, treatment, fMRI, functional connectivity, generalization, neuroplasticity
    Publisher Identifier (DOI)
    • http://dx.doi.org/10.1016/j.bandl.2015.09.002
    Description
    • The neural mechanisms that underlie generalization of treatment-induced improvements in word finding in persons with aphasia (PWA) are currently poorly understood. This study aimed to shed light on changes in functional network connectivity underlying generalization in aphasia. To this end, we used fMRI and graph theoretic analyses to examine changes in functional connectivity after a theoretically-based word-finding treatment in which abstract words were used as training items with the goal of promoting generalization to concrete words. Ten right-handed native English-speaking PWA (7 male, 3 female) ranging in age from 47 to 75 (mean = 59) participated in this study. Direct training effects coincided with increased functional connectivity for regions involved in abstract word processing. Generalization effects coincided with increased functional connectivity for regions involved in concrete word processing. Importantly, similarities between training and generalization effects were noted as were differences between participants who generalized and those who did not.
    Publication Date
    • 2015
  • Added Creator Chaleece Sandberg (she/her)
  • Added Creator Jason w. Bohland
  • Added Creator Swathi Kiran
  • Added AbCon Treatment Connectivity_B&L_accepted.pdf
  • Updated License Show Changes
    License
    • https://creativecommons.org/licenses/by-nc-nd/4.0/
  • Published
  • Updated
  • Updated Publisher, Publication Date Show Changes
    Publisher
    • Brain and Language
    Publication Date
    • 2015
    • 2015-11