Hetero-Integration of Silicon Nanomembranes with 2D Materials for Bioresorbable, Wireless Neurochemical System

Although neurotransmitters are key substances closely related to evaluating degenerative brain diseases as well as regulating essential functions in the body, many research efforts have not been focused on direct observation of such biochemical messengers, rather on monitoring relatively associated physical, mechanical, and electrophysiological parameters. Here, a bioresorbable silicon-based neurochemical analyzer incorporated with 2D transition metal dichalcogenides is introduced as a completely implantable brain-integrated system that can wirelessly monitor time-dynamic behaviors of dopamine and relevant parameters in a simultaneous mode. An extensive range of examinations of molybdenum/tungsten disulfide (MoS2/WS2) nanosheets and catalytic iron nanoparticles (Fe NPs) highlights the underlying mechanisms of strong chemical and target-specific responses to the neurotransmitters, along with theoretical modeling tools. Systematic characterizations demonstrate reversible, stable, and long-term operational performances of the degradable bioelectronics with excellent sensitivity and selectivity over those of non-dissolvable counterparts. A complete set of in vivo experiments with comparative analysis using carbon-fiber electrodes illustrates the capability for potential use as a clinically accessible tool to associated neurodegenerative diseases.

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Work Title Hetero-Integration of Silicon Nanomembranes with 2D Materials for Bioresorbable, Wireless Neurochemical System
Access
Open Access
Creators
  1. Seung Min Yang
  2. Jae Hyung Shim
  3. Hyun-U Cho
  4. Tae-Min Jang
  5. Gwan-Jin Ko
  6. Jeongeun Shim
  7. Tae Hee Kim
  8. Jia Zhu
  9. Sangun Park
  10. Yoon Seok Kim
  11. Su-Yeon Joung
  12. Jong Chan Choe
  13. Jeong-Woong Shin
  14. Joong Hoon Lee
  15. Yu Min Kang
  16. Huanyu Cheng
  17. Youngmee Jung
  18. Chul-Ho Lee
  19. Dong Pyo Jang
  20. Suk-Won Hwang
Keyword
  1. Bioresorbable
  2. Transient
  3. 2D materials
  4. Silicon nanomembranes
  5. Neurochemical
License In Copyright (Rights Reserved)
Work Type Article
Publisher
  1. Advanced Materials
Publication Date January 24, 2022
Publisher Identifier (DOI)
  1. https://doi.org/10.1002/adma.202108203
Deposited July 19, 2022

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Work History

Version 1
published

  • Created
  • Added manuscript.pdf
  • Added Creator Seung Min Yang
  • Added Creator Jae Hyung Shim
  • Added Creator Hyun U. Cho
  • Added Creator Tae Min Jang
  • Added Creator Gwan Jin Ko
  • Added Creator Jeongeun Shim
  • Added Creator Tae Hee Kim
  • Added Creator Jia Zhu
  • Added Creator Sangun Park
  • Added Creator Yoon Seok Kim
  • Added Creator Su Yeon Joung
  • Added Creator Jong Chan Choe
  • Added Creator Jeong Woong Shin
  • Added Creator Joong Hoon Lee
  • Added Creator Yu Min Kang
  • Added Creator Huanyu Cheng
  • Added Creator Youngmee Jung
  • Added Creator Chul Ho Lee
  • Added Creator Dong Pyo Jang
  • Added Creator Suk Won Hwang
  • Published
  • Updated Keyword, Publication Date Show Changes
    Keyword
    • Bioresorbable, Transient, 2D materials, Silicon nanomembranes, Neurochemical
    Publication Date
    • 2022-04-07
    • 2022-01-24
  • Renamed Creator Hyun-U Cho Show Changes
    • Hyun U. Cho
    • Hyun-U Cho
  • Renamed Creator Tae-Min Jang Show Changes
    • Tae Min Jang
    • Tae-Min Jang
  • Renamed Creator Gwan-Jin Ko Show Changes
    • Gwan Jin Ko
    • Gwan-Jin Ko
  • Renamed Creator Su-Yeon Joung Show Changes
    • Su Yeon Joung
    • Su-Yeon Joung
  • Renamed Creator Jeong-Woong Shin Show Changes
    • Jeong Woong Shin
    • Jeong-Woong Shin
  • Renamed Creator Chul-Ho Lee Show Changes
    • Chul Ho Lee
    • Chul-Ho Lee
  • Renamed Creator Suk-Won Hwang Show Changes
    • Suk Won Hwang
    • Suk-Won Hwang
  • Updated