Synergy

Summary: Combinations of multiple pharmacological agents can achieve a substantial benefit over treatment with single agents alone. Combinations that achieve 'more than the sum of their parts' are called synergistic. There have been many proposed frameworks to understand and quantify drug combination synergy with different assumptions and domains of applicability. We introduce here synergy, a Python library that (i) implements a broad array of popular synergy models, (ii) provides tools for evaluating confidence intervals and conducting power analysis and (iii) provides standardized tools to analyze and visualize drug combinations and their synergies and antagonisms.

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Work Title Synergy
Subtitle A Python library for calculating, analyzing and visualizing drug combination synergy
Access
Open Access
Creators
  1. David J. Wooten
  2. Réka Albert
License In Copyright (Rights Reserved)
Work Type Article
Publisher
  1. Bioinformatics
Publication Date May 15, 2021
Publisher Identifier (DOI)
  1. https://doi.org/10.1093/bioinformatics/btaa826
Deposited August 01, 2022

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Version 1
published

  • Created
  • Added PyPI_Synergy.pdf
  • Added Creator David J. Wooten
  • Added Creator Réka Albert
  • Published
  • Updated