External Disturbances Impact Helminth-Host Interactions by affecting Dynamics Of Infection, Parasite Traits And Host Immune Responses

Cattadori IM, Pathak A and Ferrari MJ. 2019, Ecology and Evolution 1. External perturbations, such as multi-species infections or anthelmintic treatments, can alter host-parasite interactions with consequences on the dynamics of infection. While the overall profile of infection might appear fundamentally conserved at the host population level, perturbations can disproportionately affect components of parasite demography or host responses, and ultimately impact parasite fitness and long-term persistence. 2. We took an immuno-epidemiological approach to this reasoning and examined a rabbit-helminth system where animals were trickle dosed with either one or two helminth species, treated halfway through the experiment with an anthelmintic and re-infected one month later following the same initial regime. Parasite traits (body length and fecundity) and host immune responses (cytokines, transcription factors, antibodies) were quantified at fixed time points and compared before and after drug treatment, and between single and dual infections. 3. Findings indicated a resistant host phenotype to Trichostrongylus retortaeformis where abundance, body length and fecundity were regulated by a protective immune response. In contrast, Graphidium strigosum accumulated in the host and, while it stimulated a clear immune reaction, many genes were down regulated both following re-infection and in dual infection, suggestive of a low host resistance. 4. External perturbations affected parasite fecundity, including body length and number of eggs in utero, more significantly than abundance; however, there was no consistency in the parasite-immune relationships. 5. Disentangling the processes affecting parasite life history, and how they relate to host responses, can provide a better understanding of how external disturbances impact disease severity and transmission, and how parasites strategies adjust to secure persistence at the host and the population level.

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Work Title External Disturbances Impact Helminth-Host Interactions by affecting Dynamics Of Infection, Parasite Traits And Host Immune Responses
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Open Access
Creators Isabella Cattadori
Version number 1
Keyword Helminths, rabbit, parasite traits, immune response, anthelmintic treatment, single and dual infections.
License Public Domain Mark 1.0
Work Type Dataset
DOI doi:10.26207/50s0-vk90
Deposited October 15, 2019 15:19

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  • Added Cattadori_et_al._2019_EE_worm_count.xls
  • Added Cattadori_et_al._2019_EE_worm_biometry.xls
  • Added Cattadori_et_al._2019_EE_immunity.xls
  • Added Creator Isabella Cattadori
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