Effects of VAD-Induced Shear Rates on Platelet Adhesion

Acquired von Willebrand syndrome is a disease present in many patients with ventricular assist devices (VAD) which causes dysfunction in the protein von Willebrand factor (vWF). This study shows how shear rates seen in VAD-induced flow can affect platelet adhesion due to platelet dependence on vWF interactions. Shear rate and presence of vWF cleaving protease ADAMTS-13 are shown to have a significant effect on the ability of platelets to adhere to an injury site.

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Work Title Effects of VAD-Induced Shear Rates on Platelet Adhesion
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Open Access
Creators
  1. Shane Colin Ward
Keyword
  1. Undergraduate Research Award: Excellence in Information Literacy
  2. Biomedical engineering
  3. vWF
  4. VAD
License CC BY 4.0 (Attribution)
Work Type Poster
Publication Date 2021
Deposited May 15, 2021

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Version 1
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  • Created
  • Added Creator Shane Colin Ward
  • Added ShaneWardUREPoster.pdf
  • Updated License Show Changes
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    • https://creativecommons.org/licenses/by/4.0/
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