Reversed effects of RU486 and anisomycin on memory retention of light exposure or corticosterone facilitation in the dark-incubated chicks

Memory formation for a weak passive avoidance task in the dark-incubated chicks is facilitated by light exposure or corticosterone administration at optimally pre-hatch time points. To explore the potential mechanisms underlying activation of brain memory function development by light or corticosterone exposure during late embryo, steroid receptor antagonist RU486, or protein synthetic inhibitor anisomycin, was administered intraembryonically to the embryos of either only 24-h light-exposure or complete dark-hatched on embryonic day 20 (E20). The results showed that RU486 and anisomycin significantly retarded the facilitated retention both by light and corticosterone exposure in the dark-incubated chicks. They also suggest that the act of corticosterone or light exposure on the development of brain memory function is mediated by the effect of steroid receptor, or afterward on related protein syntheses that is involved in memory formation of post-hatched performance of day-old chicks.

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Work Title Reversed effects of RU486 and anisomycin on memory retention of light exposure or corticosterone facilitation in the dark-incubated chicks
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Open Access
Creators
  1. Nan Sui
  2. Jiafen Hu
  3. Jing Chen
  4. Peizi Kuang
  5. Darrell Joyce
Keyword
  1. Anisomycin
  2. Brain
  3. Corticosterone
  4. Day-old chicks
  5. Development
  6. Memory
  7. RU486
License In Copyright (Rights Reserved)
Work Type Article
Publisher
  1. Journal of Psychopharmacology
Publication Date July 2001
Publisher Identifier (DOI)
  1. https://doi.org/10.1177/026988110101500413
Deposited January 30, 2023

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Version 1
published

  • Created
  • Added 2001_RU486-026988110101500413.pdf
  • Added Creator Nan Sui
  • Added Creator Jiafen Hu
  • Added Creator Jing Chen
  • Added Creator Peizi Kuang
  • Added Creator Darrell Joyce
  • Published
  • Updated Keyword, Publication Date Show Changes
    Keyword
    • Anisomycin, Brain, Corticosterone, Day-old chicks, Development, Memory, RU486
    Publication Date
    • 2001-01-01
    • 2001-07
  • Updated Description Show Changes
    Description
    • Memory formation for a weak passive avoidance task in the dark-incubated chicks is facilitated by lightexposure or corticosterone administration at optimally pre-hatch time points. To explore the potentialmechanisms underlying activation of brain memory function development by light or corticosteroneexposure during late embryo, steroid receptor antagonist RU486, or protein synthetic inhibitor anisomycin,was administered intraembryonically to the embryos of either only 24-h light-exposure or complete dark-hatched on embryonic day 20 (E20). The results showed that RU486 and anisomycin significantly retardedthe facilitated retention both by light and corticosterone exposure in the dark-incubated chicks. They alsosuggest that the act of corticosterone or light exposure on the development of brain memory function ismediated by the effect of steroid receptor, or afterward on related protein syntheses that is involved inmemory formation of post-hatched performance of day-old chicks.
    • Memory formation for a weak passive avoidance task in the dark-incubated chicks is facilitated by light exposure or corticosterone administration at optimally pre-hatch time points. To explore the potential mechanisms underlying activation of brain memory function development by light or corticosterone exposure during late embryo, steroid receptor antagonist RU486, or protein synthetic inhibitor anisomycin, was administered intraembryonically to the embryos of either only 24-h light-exposure or complete dark-hatched on embryonic day 20 (E20). The results showed that RU486 and anisomycin significantly retarded the facilitated retention both by light and corticosterone exposure in the dark-incubated chicks. They also suggest that the act of corticosterone or light exposure on the development of brain memory function is mediated by the effect of steroid receptor, or afterward on related protein syntheses that is involved in memory formation of post-hatched performance of day-old chicks.