Special Considerations of Anastomotic Leaks in Crohn's Disease

Rates of anastomotic leak following intestinal resections in the setting of inflammatory bowel disease are significantly influenced by clinical characteristics. While the literature can be contradictory due to significant heterogeneity in the published data, several common themes appear to consistently arise. With respect to Crohn's disease, low serum albumin, preoperative abscess, reoperative abdominal surgery, and steroid use are associated with an increased risk of postoperative intra-abdominal septic complications. On the contrary, biologic therapy, immunomodulator use, and method of anastomosis appear not to confer increased anastomotic-related complications. Undoubtedly, a low rate of anastomotic leakage is inherent to procedures within colorectal surgery but diligent attention must be paid to identify, optimize, and, therefore, reduce known risks.

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Work Title Special Considerations of Anastomotic Leaks in Crohn's Disease
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Open Access
Creators
  1. N. Nimalan A. Jeganathan
  2. Walter A. Koltun
Keyword
  1. Crohn’s disease
  2. Anastomotic leak
  3. Hypoalbuminemia
  4. Intra-abdominal abscess
  5. Steroids
  6. Biologics
License In Copyright (Rights Reserved)
Work Type Article
Publisher
  1. Clinics in Colon and Rectal Surgery
Publication Date October 1, 2021
Publisher Identifier (DOI)
  1. https://doi.org/10.1055/s-0041-1735273
Deposited July 20, 2022

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Version 1
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  • Created
  • Added Special_considerations_of_anastomotic_leaks_in_Crohn_s_disease.pdf
  • Added Creator N. Nimalan A. Jeganathan
  • Added Creator Walter A. Koltun
  • Published
  • Updated Keyword, Publication Date, Publisher's Statement Show Changes
    Keyword
    • Crohn’s disease, Anastomotic leak, Hypoalbuminemia, Intra-abdominal abscess, Steroids, Biologics
    Publication Date
    • 2021-11-01
    • 2021-10-01
    Publisher's Statement
    • Rates of anastomotic leak following intestinal resections in the setting of inflammatory bowel disease are significantly influenced by clinical characteristics. While the literature can be contradictory due to significant heterogeneity in the published data, several common themes appear to consistently arise. With respect to Crohn's disease, low serum albumin, preoperative abscess, reoperative abdominal surgery, and steroid use are associated with an increased risk of postoperative intra-abdominal septic complications. On the contrary, biologic therapy, immunomodulator use, and method of anastomosis appear not to confer increased anastomotic-related complications. Undoubtedly, a low rate of anastomotic leakage is inherent to procedures within colorectal surgery but diligent attention must be paid to identify, optimize, and, therefore, reduce known risks.
  • Updated