Validation of Hagerman’s behavioral phenotype for fragile X syndrome among men with intellectual disability

The behavioural phenotype of fragile X syndrome (FXS) and intellectual disability proposed by Hagerman et al. (2009) was primarily based on data from male children and teens. To better assist this population, there is also a need to understand how this condition manifests in adults. Eighteen carriers of FXS were paired with carriers of Down syndrome on the basis of age and level of intellectual disability. A screening checklist was created on the basis of existing scales and the Hagerman et al. (2009) behavioural phenotype and completed by care providers. Five of the 12 features of the phenotype were significantly more present among men with FXS than in men with Down syndrome. This study provides partial confirmation for Hagerman et al.’s (2009) behavioural phenotype of FXS among men with moderate intellectual disability and identified some traits that warrant further investigation.

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Work Title Validation of Hagerman’s behavioral phenotype for fragile X syndrome among men with intellectual disability
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Open Access
Creators
  1. Jacques Bellavance
  2. Morin Diane
  3. Catherine Mello
License CC BY-NC 4.0 (Attribution-NonCommercial)
Work Type Article
Publisher
  1. Advances in Mental Health and Intellectual Disabilities
Publication Date June 19, 2021
Publisher Identifier (DOI)
  1. https://doi.org/10.1108/AMHID-09-2020-0020
Deposited November 18, 2021

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