Evaluation of Alternate Manufacturing Schemes for Cesium Iodide CT Scan Scintillation Lens

Current CT scan lenses are insufficient for bioimaging at the scale of cancer cells due to lower spectral imaging resolution. This is due to the photon scattering that occurs as x-rays go through the lens. A smaller scattering angle that provides better resolution is needed to produce a CT scan lens that can adequately accomplish this goal of bioimaging cancer cells. There is currently very little literature about synthesizing CsI crystals to form a CT scan scintillation lens. Thus, various methods of manufacturing and refining coarse CsI particles were attempted. As an alkali metal halide salt, CsI powders are made via evaporation from aqueous solutions. Therefore, a novel chemical synthesis was developed based on the Born energy of solute solubility as a function of the dielectric constant of the solvent. The Born energy approach led to a range of particle sizes depending on the aerosolized size of aqueous solutions. CsI crystals were synthesized using two different methods that control the molarity of their solutions and the velocity of which CsI is introduced to an ethanol-water mixture. The result was the nucleation and growth of crystals that varied in size. Adding dipicolinic acid into the solutions resulted in acicular crystals rather than cuboidal ones. Pressing (compaction) to manufacture lenses did not work as the samples were too friable. However, polymer CsI composites show promise as an effective and scalable approach to generating CsI CT scan lenses with better resolution. Prototypes of CsI scintillation lenses cast in epoxy were developed and sent out for further testing.

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Work Title Evaluation of Alternate Manufacturing Schemes for Cesium Iodide CT Scan Scintillation Lens
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Open Access
Creators
  1. Kyle S. Yue
  2. George S. Gines
  3. Nathaniel I. Graybill
  4. Bernadette M. Adair
  5. James H. Adair
License No Copyright - U.S.
Work Type Research Paper
Publication Date July 2022
Deposited October 10, 2023

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Version 1
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  • Updated Acknowledgments Show Changes
    Acknowledgments
    • George S. Gines, Nathaniel I. Graybill, Bernadette M. Adair, James H. Adair
  • Added Creator Kyle S. Yue
  • Added Yue _Kyle_ 2022.pdf
  • Updated Publication Date, License Show Changes
    Publication Date
    • 2022-07
    License
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  • Updated Acknowledgments Show Changes
    Acknowledgments
    • George S. Gines, Nathaniel I. Graybill, Bernadette M. Adair, James H. Adair
  • Added Creator George S. Gines
  • Added Creator Nathaniel I. Graybill
  • Added Creator Bernadette M. Adair
  • Added Creator James H. Adair
  • Updated