Mushroom consumption and risk of gastric cancer: A pooled analysis within the stomach cancer pooling project and a combined meta-analysis with other observational studies

Edible mushrooms have high concentrations of vitamins and minerals. They are considered 'functional foods' for their disease-prevention properties. Mushroom consumption may reduce the risk of gastric cancer, the fifth most common cancer worldwide. We investigated the association between mushroom consumption and gastric cancer risk in a pooled analysis within the Stomach Cancer Pooling (StoP) Project and in a meta-analysis that also included previously published studies. A total of 3900 gastric cancer cases and 7792 controls from 11 studies were included in the StoP analysis. Mushroom consumption was measured using food frequency questionnaires. Higher mushroom consumption was associated with a lower risk of gastric cancer [relative risk (RR) for the highest vs. lowest consumption categories, 0.82; 95% confidence interval (CI), 0.71-0.95]. The corresponding RRs were 0.59 (95% CI, 0.26-1.33) in a meta-analysis of four previously published studies and 0.77 for all studies combined (95% CI, 0.63-0.95; n = 15 studies). In geographic subgroup analysis, the pooled risk in Western Pacific countries was (RR, 0.59; 95% CI, 0.40-0.87; n = 6). The stronger effect in Asian countries may reflect high level of antioxidants in mushroom species consumed in Asia.

This is a pre-copyedited, author-produced version of an article accepted for publication in European Journal of Cancer Prevention. The published version of record [Mushroom consumption and risk of gastric cancer: a pooled analysis within the stomach cancer pooling project and a combined meta-analysis with other observational studies. European Journal of Cancer Prevention 32, 3 p222-228 (2023)] is available online at: 10.1097/CEJ.0000000000000754.

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Work Title Mushroom consumption and risk of gastric cancer: A pooled analysis within the stomach cancer pooling project and a combined meta-analysis with other observational studies
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Open Access
Creators
  1. Djibril M. Ba
  2. Paddy Ssentongo
  3. Claudio Pelucchi
  4. Eva Negri
  5. Domenico Palli
  6. Monica Ferraroni
  7. Zuo Feng Zhang
  8. Guo Pei Yu
  9. Shoichiro Tsugane
  10. Akihisa Hidaka
  11. Gerson Shigueaki Hamada
  12. David Zaridze
  13. Dmitry Maximovich
  14. Mireia Obón-Santacana
  15. Laura Álvarez-Álvarez
  16. Jesus Vioque
  17. Manoli Garcia De La Hera
  18. Lizbeth López-Carrillo
  19. Malaquias López-Cervantes
  20. Lina Mu
  21. Areti Lagiou
  22. Pagona Lagiou
  23. Paolo Boffetta
  24. Maria Constanza Camargo
  25. Maria Paula Curado
  26. Nuno Lunet
  27. Carlo La Vecchia
  28. Joshua Muscat
Keyword
  1. Epidemiology
  2. Gastric cancer
  3. Meta-analysis
  4. Mushrooms
  5. Pooled-analysis
License In Copyright (Rights Reserved)
Work Type Article
Publisher
  1. European Journal of Cancer Prevention
Publication Date May 2023
Publisher Identifier (DOI)
  1. https://doi.org/10.1097/CEJ.0000000000000754
Deposited January 31, 2024

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Version 1
published

  • Created
  • Added Mushroom_intake_FINAL_EJCP-Jan_2022.docx
  • Added Creator Djibril M. Ba
  • Added Creator Paddy Ssentongo
  • Added Creator Claudio Pelucchi
  • Added Creator Eva Negri
  • Added Creator Domenico Palli
  • Added Creator Monica Ferraroni
  • Added Creator Zuo Feng Zhang
  • Added Creator Guo Pei Yu
  • Added Creator Shoichiro Tsugane
  • Added Creator Akihisa Hidaka
  • Added Creator Gerson Shigueaki Hamada
  • Added Creator David Zaridze
  • Added Creator Dmitry Maximovich
  • Added Creator Mireia Obón-Santacana
  • Added Creator Laura Álvarez-Álvarez
  • Added Creator Jesus Vioque
  • Added Creator Manoli Garcia De La Hera
  • Added Creator Lizbeth López-Carrillo
  • Added Creator Malaquias López-Cervantes
  • Added Creator Lina Mu
  • Added Creator Areti Lagiou
  • Added Creator Pagona Lagiou
  • Added Creator Paolo Boffetta
  • Added Creator Maria Constanza Camargo
  • Added Creator Maria Paula Curado
  • Added Creator Nuno Lunet
  • Added Creator Carlo La Vecchia
  • Added Creator Joshua Muscat
  • Published
  • Updated Keyword, Publication Date Show Changes
    Keyword
    • Epidemiology, Gastric cancer, Meta-analysis, Mushrooms, Pooled-analysis
    Publication Date
    • 2023-05-01
    • 2023-05
  • Updated

Version 2
published

  • Created
  • Added Figure_1[1].pdf
  • Added Figure_2[1].pdf
  • Added Supplementary_Materials[1].pdf
  • Published
  • Updated