Atypical lobular hyperplasia and lobular carcinoma in situ at core needle biopsy of the breast: An incidental finding or are there characteristic imaging findings?

BACKGROUND: Atypical lobular hyperplasia and classic-type lobular carcinoma in situ, collectively known as lobular neoplasia, are classically described as incidental findings found on breast core-needle biopsy without distinguishing imaging characteristics.

OBJECTIVE: The purpose of this study was to investigate concordant imaging findings of lobular neoplasia identified at core needle biopsy after careful radiologic-pathologic correlation.

METHODS: The pathology database was searched from October 1, 2006 to October 1, 2013 for breast biopsies yielding lobular neoplasia not associated with a coexistent malignancy or other high risk lesion in the biopsy specimen.

RESULTS: Of the 482 biopsies performed containing lobular neoplasia, 65 cases had lobular neoplasia as the highest risk lesion at core-needle biopsy. Of the 65 total cases in which lobular neoplasia was the highest risk lesion, 18 (28%) cases had concordant imaging correlates. 13 of 18 (72%) cases presented as calcifications on mammography and 5 of 18 (28%) presented on magnetic resonance imaging as a focus (n = 2) or non-mass enhancement (n = 3).

CONCLUSION: With careful radiologic-pathologic correlation, mammographically detected calcifications and foci or nonmass enhancement on magnetic resonance imaging can be considered concordant imaging findings of lobular neoplasia after breast core-needle biopsy.

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Work Title Atypical lobular hyperplasia and lobular carcinoma in situ at core needle biopsy of the breast: An incidental finding or are there characteristic imaging findings?
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Open Access
Creators
  1. Barry Amos
  2. Alison Chetlen
  3. Nicole Williams
Keyword
  1. Lobular neoplasia
  2. Lobular carcinoma in situ
  3. Atypical lobular hyperplasia
  4. Core-needle biopsy
  5. Radiologic–pathologic concordance
License In Copyright (Rights Reserved)
Work Type Article
Publisher
  1. Breast Disease
Publication Date 2016
Publisher Identifier (DOI)
  1. https://doi.org/10.3233/BD-150194
Deposited July 09, 2021

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Version 1
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  • Created
  • Added ALH_and_LCIS_at_Core_Needle_Biopsy_of_Breast_Incidental_Finding_or_Characteristic_Imaging_Findings_BREAST_DISEASE_2016.pdf
  • Added Creator Barry Amos
  • Added Creator Alison Chetlen
  • Added Creator Nicole Williams
  • Published
  • Updated
  • Updated
  • Updated
  • Updated Keyword, Description, Publication Date Show Changes
    Keyword
    • Lobular neoplasia, Lobular carcinoma in situ, Atypical lobular hyperplasia, Core-needle biopsy, Radiologic–pathologic concordance
    Description
    • <p>Background: Atypical lobular hyperplasia and classic-type lobular carcinoma in situ, collectively known as lobular neoplasia, are classically described as incidental findings found on breast core-needle biopsy without distinguishing imaging characteristics. OBJECTIVE: The purpose of this study was to investigate concordant imaging findings of lobular neoplasia identified at coreneedle biopsy after careful radiologic-pathologic correlation. METHODS: The pathology database was searched from October 1, 2006 to October 1, 2013 for breast biopsies yielding lobular neoplasia not associated with a coexistent malignancy or other high risk lesion in the biopsy specimen. RESULTS: Of the 482 biopsies performed containing lobular neoplasia, 65 cases had lobular neoplasia as the highest risk lesion at core-needle biopsy. Of the 65 total cases in which lobular neoplasia was the highest risk lesion, 18 (28%) cases had concordant imaging correlates. 13 of 18 (72%) cases presented as calcifications on mammography and 5 of 18 (28%) presented on magnetic resonance imaging as a focus (n = 2) or non-mass enhancement (n = 3). CONCLUSION: With careful radiologic-pathologic correlation, mammographically detected calcifications and foci or nonmass enhancement on magnetic resonance imaging can be considered concordant imaging findings of lobular neoplasia after breast core-needle biopsy.</p>
    • <p>BACKGROUND: Atypical lobular hyperplasia and classic-type lobular carcinoma in situ, collectively known as lobular neoplasia, are classically described as incidental findings found on breast core-needle biopsy without distinguishing imaging characteristics.
    • OBJECTIVE: The purpose of this study was to investigate concordant imaging findings of lobular neoplasia identified at core needle biopsy after careful radiologic-pathologic correlation.
    • METHODS: The pathology database was searched from October 1, 2006 to October 1, 2013 for breast biopsies yielding lobular neoplasia not associated with a coexistent malignancy or other high risk lesion in the biopsy specimen.
    • RESULTS: Of the 482 biopsies performed containing lobular neoplasia, 65 cases had lobular neoplasia as the highest risk lesion at core-needle biopsy. Of the 65 total cases in which lobular neoplasia was the highest risk lesion, 18 (28%) cases had concordant imaging correlates. 13 of 18 (72%) cases presented as calcifications on mammography and 5 of 18 (28%) presented on magnetic resonance imaging as a focus (n = 2) or non-mass enhancement (n = 3).
    • CONCLUSION: With careful radiologic-pathologic correlation, mammographically detected calcifications and foci or nonmass enhancement on magnetic resonance imaging can be considered concordant imaging findings of lobular neoplasia after breast core-needle biopsy.</p>
    Publication Date
    • 2016-01-01
    • 2016