Prevalence of hypermobile Ehlers-Danlos syndrome in postural orthostatic tachycardia syndrome.

Despite well-established clinical associations between Hypermobile Ehlers-Danlos syndrome (hEDS) and postural orthostatic tachycardia syndrome (POTS), the precise prevalence is unknown. We therefore evaluated for hEDS in 91 POTS participants using the 2017 hEDS diagnostic checklist, which has three major criteria: 1) generalized joint hypermobility (Beighton score), 2) systemic features, family history, and 3) absence of exclusion criteria. Overall, 28 out of 91 POTS participants (31%) met clinical criteria for hEDS. An additional 24% of participants had generalized joint hypermobility without meeting hEDS criteria. Identifying the prevalence of hEDS in POTS is important for understanding possible mechanisms connecting these two syndromes.

© This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/

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Work Title Prevalence of hypermobile Ehlers-Danlos syndrome in postural orthostatic tachycardia syndrome.
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Open Access
Creators
  1. Amanda J. Miller
  2. Lauren E. Stiles
  3. Timothy Sheehan
  4. Rebecca Bascom
  5. Howard P. Levy
  6. Clair A. Francomano
  7. Amy C. Arnold
License CC BY-NC-ND 4.0 (Attribution-NonCommercial-NoDerivatives)
Work Type Article
Publisher
  1. Elsevier BV
Publication Date March 2020
Publisher Identifier (DOI)
  1. 10.1016/j.autneu.2020.102637
Source
  1. Autonomic Neuroscience
Deposited September 09, 2021

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Version 1
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  • Created
  • Added A Arnold - Prevalence of hypermobile_postprint.docx
  • Added Creator Amanda J. Miller
  • Added Creator Lauren E. Stiles
  • Added Creator Timothy Sheehan
  • Added Creator Rebecca Bascom
  • Added Creator Howard P. Levy
  • Added Creator Clair A. Francomano
  • Added Creator Amy C. Arnold
  • Published
  • Updated
  • Updated
  • Updated