Analyzing Effects of Different Medications on Length of Stay in Hospital After Colon Surgery for Crohn's Disease Patients
According to the CDC’s most recent data, there are currently over 3 million adults living in the US living with Crohn’s disease, which is a type of inflammatory bowel disease (IBD). Around 20-50% of those suffering from the disease require surgery to reduce and manage their symptoms. Some of the patients diagnosed with Crohn’s disease undergo a surgery called ileocolectomy, where certain areas of the small and large intestines affected by the disease are removed. As it is a major procedure, it is usually an inpatient encounter, where the patient stays in the hospital for a few days after surgery. During the period leading up to and after the procedure, the patient is administered different medication to ensure smooth recovery. Various aspects, such as infection, inflammation, pain relief and more are tended to by these drugs. Apart from the time during surgery, there are two main types of drugs that are used to help reduce inflammation and ease the effects of Crohn’s disease – Biologics and Steroids. Both classes of drugs are anti-inflammatory drugs. Steroids work by suppressing the entire immune system, while biologics target specific proteins in the immune system that have been proven to be associated with Crohn’s inflammation. As such, a person suffering from Crohn’s disease is usually administered one or both drugs, which could potentially affect the length of stay (LOS) in the hospital post-surgery. Deidentified patient records are obtained from TriNetX, which is a vast database of medical records that include clinical patient data such as demographics, diagnoses, procedures and so on, which are collected from Electronic Medical Records (EMR) systems of healthcare organizations from across the US. These records were sorted to include the patients relevant to this study, and, after the implantation of several criteria, a final cohort was arrived at. Various statistical analyses such as hypothesis testing and linear regression were carried out, and the results were that those administered steroids or both drugs had a lower LOS than those administered just Biologics, but these results were not significant enough to conclude the same holds true for the general population. This study hopes to provide the platform for further improvements to arrive at a conclusion that the effects of different medication are significant enough to make a difference on the LOS and provide such data to healthcare professionals for real-world use.
Advisor: Dr. Qiushi Chen
|Work Title||Analyzing Effects of Different Medications on Length of Stay in Hospital After Colon Surgery for Crohn's Disease Patients|
|License||CC BY 4.0 (Attribution)|
|Work Type||Research Paper|
|Deposited||November 04, 2022|
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