Advancing botanical safety: A strategy for selecting, sourcing, and characterizing botanicals for developing toxicological tools

Increases in botanical use, encompassing herbal medicines and dietary supplements, have underlined a critical need for an advancement in safety assessment methodologies. However, botanicals present unique challenges for safety assessment due to their complex and variable composition arising from diverse growing conditions, processing methods, and plant varieties. Historically, botanicals have been largely evaluated based on their history of use information, based primarily on traditional use or dietary history. However, this presumption lacks comprehensive toxicological evaluation, demanding innovative and consistent assessment strategies. To address these challenges, the Botanical Safety Consortium (BSC) was formed as an international, cross-sector forum of experts to identify fit-for purpose assays that can be used to evaluate botanical safety. This global effort aims to assess botanical safety assessment methodologies, merging traditional knowledge with modern in vitro and in silico assays. The ultimate goal is to champion the development of toxicity tools for botanicals. This manuscript highlights: 1) BSC's strategy for botanical selection, sourcing, and preparation of extracts to be used in in vitro assays, and 2) the approach utilized to characterize botanical extracts, using green tea and Asian ginseng as examples, to build confidence for use in biological assays.

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Work Title Advancing botanical safety: A strategy for selecting, sourcing, and characterizing botanicals for developing toxicological tools
Access
Open Access
Creators
  1. Suramya Waidyanatha
  2. Bradley J. Collins
  3. Tim Cristy
  4. Michelle Embry
  5. Stefan Gafner
  6. Holly Johnson
  7. Josh Kellogg
  8. Julie Krzykwa
  9. Siheng Li
  10. Constance A. Mitchell
  11. Esra Mutlu
  12. Sarah Pickett
  13. Hong You
  14. Richard Van Breemen
  15. Timothy R. Baker
Keyword
  1. Safety Assessment
  2. Ginseng
  3. Use History
  4. In Vitro Assay
  5. Process Plant
  6. Consistent Assessment
  7. Biological Assay
  8. Assessment Strategy
  9. Dietary History
  10. Information Centric
  11. Growing Conditions
  12. Variable Composition
  13. Fit For Purpose
  14. Complex Composition
  15. Cross Sectoral
  16. Toxicological Evaluation
  17. Traditional Knowledge
  18. Traditional Uses
  19. Innovative Assessment
  20. Herbal Medicine
  21. Botanical Extracts
  22. Plant Varieties
  23. Green Tea
  24. Processing Methods
  25. Dietary Supplements
  26. Dietary Supplement
  27. Bioassay
License CC BY-NC-ND 4.0 (Attribution-NonCommercial-NoDerivatives)
Work Type Article
Publisher
  1. Food and Chemical Toxicology
Publication Date April 1, 2024
Publisher Identifier (DOI)
  1. 10.1016/j.fct.2024.114537
Related URLs
  1. https://doi.org/10.1016/j.fct.2024.114537
Deposited February 10, 2025

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Version 1
published

  • Created

    February 10, 2025 10:39 by jjk6146

  • Updated

    February 10, 2025 10:39 by [unknown user]

  • Added Creator Suramya Waidyanatha

    February 10, 2025 10:40 by jjk6146

  • Added Creator Bradley J. Collins

    February 10, 2025 10:40 by jjk6146

  • Added Creator Tim Cristy

    February 10, 2025 10:40 by jjk6146

  • Added Creator Michelle Embry

    February 10, 2025 10:40 by jjk6146

  • Added Creator Stefan Gafner

    February 10, 2025 10:40 by jjk6146

  • Added Creator Holly Johnson

    February 10, 2025 10:40 by jjk6146

  • Added Creator Josh Kellogg

    February 10, 2025 10:40 by jjk6146

  • Added Creator Julie Krzykwa

    February 10, 2025 10:40 by jjk6146

  • Added Creator Siheng Li

    February 10, 2025 10:40 by jjk6146

  • Added Creator Constance A. Mitchell

    February 10, 2025 10:40 by jjk6146

  • Added Creator Esra Mutlu

    February 10, 2025 10:40 by jjk6146

  • Added Creator Sarah Pickett

    February 10, 2025 10:40 by jjk6146

  • Added Creator Hong You

    February 10, 2025 10:40 by jjk6146

  • Added Creator Richard Van Breemen

    February 10, 2025 10:40 by jjk6146

  • Added Creator Timothy R. Baker

    February 10, 2025 10:40 by jjk6146

  • Updated Keyword, Publisher, Publisher Identifier (DOI), and 3 more Show Changes

    February 10, 2025 10:40 by jjk6146

    Keyword
    • Safety Assessment, Ginseng, Use History, In Vitro Assay, Process Plant, Consistent Assessment, Biological Assay, Assessment Strategy, Dietary History, Information Centric, Growing Conditions, Variable Composition, Fit For Purpose, Complex Composition, Cross Sectoral, Toxicological Evaluation, Traditional Knowledge, Traditional Uses, Innovative Assessment, Herbal Medicine, Botanical Extracts, Plant Varieties, Green Tea, Processing Methods, Dietary Supplements, Dietary Supplement, Bioassay
    Publisher
    • Food and Chemical Toxicology
    Publisher Identifier (DOI)
    • 10.1016/j.fct.2024.114537
    Related URLs
    • https://doi.org/10.1016/j.fct.2024.114537
    Description
    • <p>Increases in botanical use, encompassing herbal medicines and dietary supplements, have underlined a critical need for an advancement in safety assessment methodologies. However, botanicals present unique challenges for safety assessment due to their complex and variable composition arising from diverse growing conditions, processing methods, and plant varieties. Historically, botanicals have been largely evaluated based on their history of use information, based primarily on traditional use or dietary history. However, this presumption lacks comprehensive toxicological evaluation, demanding innovative and consistent assessment strategies. To address these challenges, the Botanical Safety Consortium (BSC) was formed as an international, cross-sector forum of experts to identify fit-for purpose assays that can be used to evaluate botanical safety. This global effort aims to assess botanical safety assessment methodologies, merging traditional knowledge with modern in vitro and in silico assays. The ultimate goal is to champion the development of toxicity tools for botanicals. This manuscript highlights: 1) BSC's strategy for botanical selection, sourcing, and preparation of extracts to be used in in vitro assays, and 2) the approach utilized to characterize botanical extracts, using green tea and Asian ginseng as examples, to build confidence for use in biological assays.</p>
    Publication Date
    • 2024-04-01
  • Updated

    February 10, 2025 10:40 by jjk6146

  • Updated

    February 10, 2025 10:40 by jjk6146

  • Updated Creator Suramya Waidyanatha

    February 10, 2025 10:40 by jjk6146

  • Updated Creator Bradley J. Collins

    February 10, 2025 10:40 by jjk6146

  • Updated Creator Tim Cristy

    February 10, 2025 10:40 by jjk6146

  • Updated Creator Michelle Embry

    February 10, 2025 10:40 by jjk6146

  • Updated Creator Stefan Gafner

    February 10, 2025 10:40 by jjk6146

  • Updated Creator Holly Johnson

    February 10, 2025 10:40 by jjk6146

  • Updated Creator Josh Kellogg

    February 10, 2025 10:40 by jjk6146

  • Updated Creator Julie Krzykwa

    February 10, 2025 10:40 by jjk6146

  • Updated Creator Siheng Li

    February 10, 2025 10:40 by jjk6146

  • Updated Creator Constance A. Mitchell

    February 10, 2025 10:40 by jjk6146

  • Updated Creator Esra Mutlu

    February 10, 2025 10:40 by jjk6146

  • Updated Creator Sarah Pickett

    February 10, 2025 10:40 by jjk6146

  • Updated Creator Hong You

    February 10, 2025 10:40 by jjk6146

  • Updated Creator Richard Van Breemen

    February 10, 2025 10:40 by jjk6146

  • Updated Creator Timothy R. Baker

    February 10, 2025 10:40 by jjk6146

  • Added Waidyanatha et al_2024_Advancing botanical safety.pdf

    February 10, 2025 10:40 by jjk6146

  • Updated License Show Changes

    February 10, 2025 10:40 by jjk6146

    License
    • https://creativecommons.org/licenses/by-nc-nd/4.0/
  • Published

    February 10, 2025 10:40 by jjk6146

  • Updated

    February 10, 2025 21:04 by [unknown user]