# jc.2020-01551: "Effects of Oral Contraception and Lifestyle Modification on Circulating Hormones in Polycystic Ovary Syndrome"

ABSTRACT # jc.2020-01551 Objective: To examine the effects of common treatments for polycystic ovary syndrome( PCOS) on a panel of reproductive and metabolic hormones. Design: Secondary analysis of blood samples from a randomized controlled trial of three 16 week preconception interventions designed to improve the PCOS phenotype: continuous oral contraceptives(OCP), intensive lifestyle intervention(Lifestyle) or combination of both(Combined). Materials and Methods: Post-treatment levels of activin A and B, inhibin B and follistatin as well as IGF-1, IGFBP-2, glucagon, GLP-1 and 2 and Oxyntomodulin at 16 weeks were compared to baseline and between groups. Correlations with change in key parameters were made. Results: OCP use was associated with a significant suppression in activin A, inhibin A and AMH, but significant increase in follistatin. There was also a significant decrease in IGF-1, IGFBP-2, glucagon and GLP-2 levels. Plasma oxyntomodulin was the analyte most profoundly suppressed by OCP [mean gemometric mean from baseline: 0.09, 95% CI(0.05, 0.18)]. None of the measured anlytes were significantly affected by Lifestyle, whereas Combined showed similar effects of OCP alone, although attenuated. Oxyntomodulin levels were significantly positively associated with change in total ovarian volume [rs = 0.27; 95% CI: (0.03, 0.48)] and insulin sensitivity index [rs = 0.48; 95% CI: (0.27, 0.64)] and inversely correlated with change in AUC glucose [rs = -0.38; 95% CI: (-0.57, -0.16)]. Conclusions: In women with PCOS, OCP affects a wide variety of reproductive and metabolic hormones while the changes associated with lifestyle intervention are negligible.

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Work Title # jc.2020-01551: "Effects of Oral Contraception and Lifestyle Modification on Circulating Hormones in Polycystic Ovary Syndrome"
Subtitle Supplementary Materials
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Open Access
Creators
  1. Christina Stetter
Keyword
  1. insulin resistance
  2. obesity
  3. incretins
  4. hyperandrogenism
  5. inflammation
License All rights reserved
Work Type Journal
Deposited August 03, 2020

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  • Added Legro_Supplemental_Repository.pdf
  • Added Creator Christina Stetter
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