Kingdom-Wide Analysis of Fungal Small Secreted Proteins (SSPs) Reveals their Potential Role in Host Association

Fungal secretome consists of various functional groups of proteins, many of which participate in nutrient acquisition, self-protection, or manipulation of the environment and neighboring organisms. The least characterized component of the secretome is small secreted proteins (SSPs). Some SSPs have been reported to function as effectors, but most remain to be characterized. The composition of major secretome components, such as carbohydrate-active enzymes, proteases, lipases, and oxidoreductases, appear to reflect the lifestyle and ecological niche of individual species. We hypothesize that many SSPs participate in manipulating plants as effectors. Obligate biotrophs likely encode more and diverse effector-like SSPs to suppress host defense compared to necrotrophs, which generally use cell wall degrading enzymes and phytotoxins to kill hosts. Because different secretome prediction workflows have been used in different studies, available secretome data are difficult to integrate for comprehensive comparative studies to test this hypothesis. In this study, SSPs encoded by 136 fungal species were identified from data archived in Fungal Secretome Database (FSD) via a refined secretome workflow. Subsequently, compositions of SSPs and other secretome components were compared in light of taxa and lifestyles. Those species that are intimately associated with host cells, such as biotrophs and symbionts, usually have higher proportion of species-specific SSPs (SSSPs) than hemibiotrophs and necrotrophs, but the latter groups displayed higher proportions of secreted enzymes. Results from our study established a foundation for functional studies on SSPs and will also help understand genomic changes potentially underpinning different fungal lifestyles.

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Work Title Kingdom-Wide Analysis of Fungal Small Secreted Proteins (SSPs) Reveals their Potential Role in Host Association
Access
Open Access
Creators
  1. Ki-Tae Kim
  2. Jongbum Jeon
  3. Jaeyoung Choi
  4. Kyeongchae Cheong
  5. Hyeunjeong Song
  6. Gobong Choi
  7. Seogchan Kang
  8. Yong-Hwan Lee
Keyword
  1. Fungi
  2. Lifestyle
  3. Secretome
  4. Small secreted proteins
  5. Effectors
License In Copyright (Rights Reserved)
Work Type Article
Publisher
  1. Frontiers in Plant Science
Publication Date February 19, 2016
Publisher Identifier (DOI)
  1. http://dx.doi.org/10.3389/fpls.2016.00186
Deposited March 13, 2024

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Version 1
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  • Created
  • Added Kim__2016_.pdf
  • Added Creator K Kim
  • Added Creator J Jeon
  • Added Creator J Choi
  • Added Creator K Cheong
  • Added Creator H Song
  • Added Creator G Choi
  • Added Creator Seogchan Kang
  • Added Creator Y H Lee
  • Published
  • Updated Work Title Show Changes
    Work Title
    • Kingdom-wide analysis of fungal secretomes, with the focus on small secreted proteins, to evaluate their role in different lifestyles
    • Kingdom-Wide Analysis of Fungal Small Secreted Proteins (SSPs) Reveals their Potential Role in Host Association
  • Updated Keyword, Publisher Identifier (DOI) Show Changes
    Keyword
    • Fungi, Lifestyle, Secretome, Small secreted proteins, Effectors
    Publisher Identifier (DOI)
    • https://doi.org/10.3389/fpls.2016.00186/full
    • http://dx.doi.org/10.3389/fpls.2016.00186
  • Renamed Creator Ki-Tae Kim Show Changes
    • K Kim
    • Ki-Tae Kim
  • Renamed Creator Jongbum Jeon Show Changes
    • J Jeon
    • Jongbum Jeon
  • Renamed Creator Jaeyoung Choi Show Changes
    • J Choi
    • Jaeyoung Choi
  • Renamed Creator Kyeongchae Cheong Show Changes
    • K Cheong
    • Kyeongchae Cheong
  • Renamed Creator Hyeunjeong Song Show Changes
    • H Song
    • Hyeunjeong Song
  • Renamed Creator Gobong Choi Show Changes
    • G Choi
    • Gobong Choi
  • Renamed Creator Yong-Hwan Lee Show Changes
    • Y H Lee
    • Yong-Hwan Lee
  • Updated