Attention and executive function are impaired during active standing in postural tachycardia syndrome

Postural tachycardia syndrome (POTS) is a chronic form of orthostatic intolerance associated with cognitive dysfunction. We hypothesized executive function and attention is impaired in POTS during active standing. Eighty-seven POTS participants and 39 healthy controls of similar age, sex, and education level completed executive function (Stroop word-color) and attention (CogState Identification) tests in supine and standing postures in a cross-sectional study. POTS participants had lower executive function (t-score: 48 ± 11 vs. 55 ± 10 control; p = 0.009) and worse attention (reaction speed: 2.78 ± 0.11 vs. 2.69 ± 0.06 control; p < 0.001) during standing. These data provide new evidence that active standing impairs attention and executive functioning in POTS.

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Work Title Attention and executive function are impaired during active standing in postural tachycardia syndrome
Access
Open Access
Creators
  1. Amanda Joy Miller
  2. Timothy Sheehan
  3. Kate M. Bourne
  4. Monica Feeley
  5. Amy C. Arnold
Keyword
  1. Postural tachycardia syndrome, cognition, brain fog, orthostatic intolerance
License Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Work Type Article
Publisher
  1. Autonomic Neuroscience: Basic and Clinical
Publication Date June 5, 2020
Publisher Identifier (DOI)
  1. https://doi.org/10.1016/j.autneu.2020.102692
Deposited February 24, 2021 13:55

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Version 1
published

  • Created
  • Added Creator Amanda Joy Miller
  • Added Creator Timothy Sheehan
  • Added Creator Kate M. Bourne
  • Added Creator Amy Arnold
  • Added Creator Monica Feeley
  • Renamed Creator Amy C. Arnold Show Changes
    • Amy Arnold
    • Amy C. Arnold
  • Added AUTNEU_2020_3 R2 Clean Manuscript.docx
  • Updated Publisher, Publisher Identifier (DOI), License Show Changes
    Publisher
    • Autonomic Neuroscience: Basic and Clinical
    Publisher Identifier (DOI)
    • https://doi.org/10.1016/j.autneu.2020.102692
    License
    • https://creativecommons.org/licenses/by-nc-nd/4.0/
  • Published