Comparison of modulation of Kv1.3 channel by two receptor tyrosine kinases in olfactory bulb neurons of rodents

Activation of the receptor tyrosine kinase (RTK), insulin (IRK) or neurotrophin B (TrkB), was characterized and compared in olfactory bulb neuron (OBN) cultures from Sprague Dawley rats and sv129 B6 mice. Current suppression attributed to modulation of the delayed rectifier, Kv1.3, a voltage-gated potassium (Kv) channel of the Shaker family, was observed following acute application of the growth factors, insulin or brain-derived neurotrophic factor (BDNF), to mitral cells of either rodent model. Using site-directed mutagenesis of putative tyrosine phosphorylation recognition motifs in the channel, we find that stimulation of Kv1.3 with these growth factors causes multiple phosphorylation, albeit via different residue combinations that are RTK specific.

This is an Accepted Manuscript of an article published by Taylor & Francis in Receptors and Channels on 2004-01-01, available online: https://www.tandfonline.com/10.3109/10606820490270870.

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Work Title Comparison of modulation of Kv1.3 channel by two receptor tyrosine kinases in olfactory bulb neurons of rodents
Access
Open Access
Creators
  1. B. Colley
  2. K. Tucker
  3. D. A. Fadool
Keyword
  1. BDNF
  2. Insulin
  3. Neurotrophin
  4. Olfactory
  5. TrkB
  6. Tyrosine phosphorylation
License CC BY-NC 4.0 (Attribution-NonCommercial)
Work Type Article
Publisher
  1. Receptors and Channels
Publication Date March 19, 2004
Publisher Identifier (DOI)
  1. https://doi.org/10.3109/10606820490270870
Deposited November 21, 2023

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Version 1
published

  • Created
  • Added Colley_et_al_2004-2.pdf
  • Added Creator B. Colley
  • Added Creator K. Tucker
  • Added Creator Debra Ann Fadool
  • Published
  • Updated Keyword Show Changes
    Keyword
    • BDNF, Insulin, Neurotrophin, Olfactory, TrkB, Tyrosine phosphorylation
  • Renamed Creator D. A. Fadool Show Changes
    • Debra Ann Fadool
    • D. A. Fadool
  • Updated