itMatters: Optimization of an online intervention to prevent sexually transmitted infections in college students

To describe an iterative approach to developing an online intervention targeting the intersection of alcohol use and sexual behaviors among first year college students. Methods and Participants: Using the multiphase optimization strategy (MOST), we conducted two iterative optimization trials to: (1) identify candidate intervention components (i.e., descriptive norms, injunctive norms, outcome expectancies, perceived benefits of protective behavioral strategies, and self-efficacy to use strategies); (2) revise components; and (3) identify the optimized intervention. Participants were first year college students at six geographically diverse universities (optimization trial 1 N = 5,880; optimization trial 2 N = 3,551) Results: For both optimization trials, the results indicated that only descriptive and injunctive norms produced a significant effect (p<.05). Conclusions: The iterative process of MOST allowed us to develop an optimized intervention which is an essential tool to maximize intervention effectiveness and efficiency to improve uptake, sustainability, and public health impact.

This is an Accepted Manuscript of an article published by Taylor & Francis in 'Journal of American College Health' on 2020-07-21, available online:


  • JACH_CSE-paper_v3-1.docx

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Work Title itMatters: Optimization of an online intervention to prevent sexually transmitted infections in college students
Open Access
  1. David L. Wyrick
  2. Amanda E. Tanner
  3. Jeffrey J. Milroy
  4. Kate Guastaferro
  5. Sandesh Bhandari
  6. Kari C. Kugler
  7. Shemeka Thorpe
  8. Samuella Ware
  9. Alicia M. Miller
  10. Linda M. Collins
License In Copyright (Rights Reserved)
Work Type Article
  1. Informa UK Limited
Publication Date July 21, 2020
Publisher Identifier (DOI)
  1. 10.1080/07448481.2020.1790571
  1. Journal of American College Health
Deposited February 23, 2022




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Work History

Version 1

  • Created
  • Added JACH_CSE-paper_v3-1.docx
  • Added Creator David L. Wyrick
  • Added Creator Amanda E. Tanner
  • Added Creator Jeffrey J. Milroy
  • Added Creator Kate Guastaferro
  • Added Creator Sandesh Bhandari
  • Added Creator Kari C. Kugler
  • Added Creator Shemeka Thorpe
  • Added Creator Samuella Ware
  • Added Creator Alicia M. Miller
  • Added Creator Linda M. Collins
  • Published
  • Updated
  • Updated
  • Updated