The effects of exercise and diet on sex steroids in breast cancer survivors

Insufficient physical activity and obesity are associated with an increased risk of cancer recurrence and death in breast cancer survivors. Sex steroid hormones may mediate these associations. This study tested the hypothesis that exercise and diet, as compared to control, favorably change sex steroid hormones. This analysis of data from a subset of participants in a 2 × 2 factorial trial compares 269 postmenopausal breast cancer survivors who were insufficiently physically active and had overweight or obesity and were randomized to one of four treatment groups for 52 weeks: control, exercise alone, diet alone, or exercise plus diet. Secondary sex steroid hormone endpoints included estradiol, sex hormone-binding globulin (SHBG), and testosterone. Treatment effects were quantified using a mixed model for repeated measures. Compared to control, exercise alone did not significantly change estradiol (-1.9%; 95% CI: -12.6, 8.8), SHBG (2.4%; 95% CI: -9.9, 14.6), or testosterone (1.2%; 95% CI: -12.2, 14.5). Compared to control, diet alone did not significantly change estradiol (-7.8%; 95% CI: -17.6, 1.9), SHBG (8.2%; 95% CI: -4.2, 20.6), or testosterone (-0.8%; 95% CI: -13.6, 12.0). Compared to control, exercise plus diet did not significantly change estradiol (-6.3%; 95% CI: -16.3, 3.6), SHBG (8.8%; 95% CI: -4.0, 21.7), or testosterone (-5.3%; 95% CI: -18.0, 7.4). In postmenopausal breast cancer survivors who were insufficiently physically active and had overweight or obesity, randomization to exercise alone, diet alone, or exercise plus diet did not statistically significantly change sex steroid hormone concentrations at week 52.

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Work Title The effects of exercise and diet on sex steroids in breast cancer survivors
Access
Open Access
Creators
  1. Justin C. Brown
  2. Kathleen Sturgeon
  3. David B. Sarwer
  4. Andrea B. Troxel
  5. Angela M. DeMichele
  6. Crystal S. Denlinger
  7. Kathryn H. Schmitz
Keyword
  1. Estradiol
  2. Exercise
  3. Obesity
  4. Sex hormone-binding globulin
  5. Testosterone
License In Copyright (Rights Reserved)
Work Type Article
Publisher
  1. Endocrine-Related Cancer
Publication Date June 29, 2022
Publisher Identifier (DOI)
  1. https://doi.org/10.1530/ERC-22-0084
Deposited February 17, 2023

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Version 1
published

  • Created
  • Added Sex_hormones_-_published.pdf
  • Added Creator Justin C. Brown
  • Added Creator Kathleen Sturgeon
  • Added Creator David B. Sarwer
  • Added Creator Andrea B. Troxel
  • Added Creator Angela M. DeMichele
  • Added Creator Crystal S. Denlinger
  • Added Creator Kathryn H. Schmitz
  • Published
  • Updated Keyword Show Changes
    Keyword
    • Estradiol, Exercise, Obesity, Sex hormone-binding globulin, Testosterone
  • Updated