Increasing the adoption of evidence-based communication practices for HPV vaccination in primary care clinics: The HPV ECHO study protocol for a cluster randomized controlled trial

Background: The safe, highly-effective human papillomavirus (HPV) vaccine remains underused in the US. The Announcement Approach Training (AAT) has been shown to effectively increase HPV vaccine uptake by training providers to make strong vaccine recommendations and answer parents' common questions. Systems communications, like recall notices, can further improve HPV vaccination by reducing missed clinical opportunities for vaccination. Never tested in supporting HPV vaccination, the ECHO (Extension for Community Healthcare Outcomes) model is a proven implementation strategy to increase best practices among healthcare providers. This trial uses a hybrid effectiveness-implementation design (type II) to evaluate two ECHO-delivered interventions intended to increase HPV vaccination rates.

Methods: This 3-arm cluster randomized controlled trial will be conducted in 36 primary care clinics in Pennsylvania. Aim 1 evaluates the impact of HPV ECHO (AAT to providers) and HPV ECHO+ (AAT to providers plus recall notices to vaccine-declining parents) versus control on HPV vaccination (≥1 dose) among adolescents, ages 11–14, between baseline and 12-month follow-up (primary outcome). Using a convergent mixed-methods approach, Aim 2 evaluates the implementation of the HPV ECHO and HPV ECHO+ interventions. Aim 3 explores exposure to and impact of vaccine information from providers and other sources (e.g., social media) on secondary acceptance among 200 HPV vaccine-declining parents within 12 months.

Discussion: We expect to demonstrate the effectiveness and evaluate the implementation of two highly scalable interventions to increase HPV vaccination in primary care clinics. Our study seeks to address the communication needs of both providers and parents, increase HPV vaccination, and, eventually, prevent HPV-related cancers.

Trial registration: ClinicalTrials.gov NCT04587167. Registered on October 14, 2020.

© This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/

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Work Title Increasing the adoption of evidence-based communication practices for HPV vaccination in primary care clinics: The HPV ECHO study protocol for a cluster randomized controlled trial
Access
Open Access
Creators
  1. William A. Calo
  2. Parth D. Shah
  3. Benjamin N. Fogel
  4. Mack T. Ruffin IV
  5. Jennifer L. Moss
  6. Bernice L. Hausman
  7. Joel E. Segel
  8. Erica Francis
  9. Eric Schaefer
  10. Chelsea M. Bufalini
  11. Nikole Johnston
  12. Ellie Hogentogler
  13. Jennifer L. Kraschnewski
Keyword
  1. Human papillomavirus vaccine
  2. Vaccine communication
  3. Healthcare providers
  4. Primary care clinics
  5. Vaccine hesitancy
  6. Implementation outcomes
License CC BY-NC-ND 4.0 (Attribution-NonCommercial-NoDerivatives)
Work Type Article
Publisher
  1. Contemporary Clinical Trials
Publication Date June 14, 2023
Publisher Identifier (DOI)
  1. https://doi.org/10.1016/j.cct.2023.107266
Deposited March 04, 2024

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  • Created

    March 04, 2024 08:25 by Researcher Metadata Database

  • Added HPV_ECHO_protocol_clean.docx

    March 04, 2024 08:25 by Researcher Metadata Database

  • Added Tables_Figures_v4.docx

    March 04, 2024 08:25 by Researcher Metadata Database

  • Added Creator William A. Calo

    March 04, 2024 08:25 by Researcher Metadata Database

  • Added Creator W Alexis Calo Perez

    March 04, 2024 08:25 by Researcher Metadata Database

  • Added Creator Parth D. Shah

    March 04, 2024 08:25 by Researcher Metadata Database

  • Added Creator Benjamin N. Fogel

    March 04, 2024 08:25 by Researcher Metadata Database

  • Added Creator M T. Ruffin

    March 04, 2024 08:25 by Researcher Metadata Database

  • Added Creator Mack T. Ruffin IV

    March 04, 2024 08:25 by Researcher Metadata Database

  • Added Creator Jennifer L. Moss

    March 04, 2024 08:25 by Researcher Metadata Database

  • Added Creator Bernice L. Hausman

    March 04, 2024 08:25 by Researcher Metadata Database

  • Added Creator Joel E. Segel

    March 04, 2024 08:25 by Researcher Metadata Database

  • Added Creator Erica Francis

    March 04, 2024 08:25 by Researcher Metadata Database

  • Added Creator Eric Schaefer

    March 04, 2024 08:25 by Researcher Metadata Database

  • Added Creator Chelsea M. Bufalini

    March 04, 2024 08:25 by Researcher Metadata Database

  • Added Creator Nikole Johnston

    March 04, 2024 08:25 by Researcher Metadata Database

  • Added Creator Ellie Hogentogler

    March 04, 2024 08:25 by Researcher Metadata Database

  • Added Creator Jennifer L. Kraschnewski

    March 04, 2024 08:25 by Researcher Metadata Database

  • Published

    March 04, 2024 08:25 by Researcher Metadata Database

  • Updated Keyword, Description, Publication Date Show Changes

    March 04, 2024 14:28 by avs5190

    Keyword
    • Human papillomavirus vaccine, Vaccine communication, Healthcare providers, Primary care clinics, Vaccine hesitancy, Implementation outcomes
    Description
    • <p>Background: The safe, highly-effective human papillomavirus (HPV) vaccine remains underused in the US. The Announcement Approach Training (AAT) has been shown to effectively increase HPV vaccine uptake by training providers to make strong vaccine recommendations and answer parents' common questions. Systems communications, like recall notices, can further improve HPV vaccination by reducing missed clinical opportunities for vaccination. Never tested in supporting HPV vaccination, the ECHO (Extension for Community Healthcare Outcomes) model is a proven implementation strategy to increase best practices among healthcare providers. This trial uses a hybrid effectiveness-implementation design (type II) to evaluate two ECHO-delivered interventions intended to increase HPV vaccination rates. Methods: This 3-arm cluster randomized controlled trial will be conducted in 36 primary care clinics in Pennsylvania. Aim 1 evaluates the impact of HPV ECHO (AAT to providers) and HPV ECHO+ (AAT to providers plus recall notices to vaccine-declining parents) versus control on HPV vaccination (≥1 dose) among adolescents, ages 11–14, between baseline and 12-month follow-up (primary outcome). Using a convergent mixed-methods approach, Aim 2 evaluates the implementation of the HPV ECHO and HPV ECHO+ interventions. Aim 3 explores exposure to and impact of vaccine information from providers and other sources (e.g., social media) on secondary acceptance among 200 HPV vaccine-declining parents within 12 months. Discussion: We expect to demonstrate the effectiveness and evaluate the implementation of two highly scalable interventions to increase HPV vaccination in primary care clinics. Our study seeks to address the communication needs of both providers and parents, increase HPV vaccination, and, eventually, prevent HPV-related cancers. Trial registration: ClinicalTrials.gov NCT04587167. Registered on October 14, 2020.</p>
    • <p>Background: The safe, highly-effective human papillomavirus (HPV) vaccine remains underused in the US. The Announcement Approach Training (AAT) has been shown to effectively increase HPV vaccine uptake by training providers to make strong vaccine recommendations and answer parents' common questions. Systems communications, like recall notices, can further improve HPV vaccination by reducing missed clinical opportunities for vaccination. Never tested in supporting HPV vaccination, the ECHO (Extension for Community Healthcare Outcomes) model is a proven implementation strategy to increase best practices among healthcare providers. This trial uses a hybrid effectiveness-implementation design (type II) to evaluate two ECHO-delivered interventions intended to increase HPV vaccination rates.
    • Methods: This 3-arm cluster randomized controlled trial will be conducted in 36 primary care clinics in Pennsylvania. Aim 1 evaluates the impact of HPV ECHO (AAT to providers) and HPV ECHO+ (AAT to providers plus recall notices to vaccine-declining parents) versus control on HPV vaccination (≥1 dose) among adolescents, ages 11–14, between baseline and 12-month follow-up (primary outcome). Using a convergent mixed-methods approach, Aim 2 evaluates the implementation of the HPV ECHO and HPV ECHO+ interventions. Aim 3 explores exposure to and impact of vaccine information from providers and other sources (e.g., social media) on secondary acceptance among 200 HPV vaccine-declining parents within 12 months.
    • Discussion: We expect to demonstrate the effectiveness and evaluate the implementation of two highly scalable interventions to increase HPV vaccination in primary care clinics. Our study seeks to address the communication needs of both providers and parents, increase HPV vaccination, and, eventually, prevent HPV-related cancers.
    • Trial registration: ClinicalTrials.gov NCT04587167. Registered on October 14, 2020.</p>
    Publication Date
    • 2023-07-01
    • 2023-06-14
  • Deleted Creator W Alexis Calo Perez

    March 04, 2024 14:28 by avs5190

  • Deleted Creator M T. Ruffin

    March 04, 2024 14:28 by avs5190

  • Updated Creator Parth D. Shah

    March 04, 2024 14:28 by avs5190

  • Updated Creator Benjamin N. Fogel

    March 04, 2024 14:28 by avs5190

  • Updated Creator Mack T. Ruffin IV

    March 04, 2024 14:28 by avs5190

  • Updated Creator Jennifer L. Moss

    March 04, 2024 14:28 by avs5190

  • Updated Creator Bernice L. Hausman

    March 04, 2024 14:28 by avs5190

  • Updated Creator Joel E. Segel

    March 04, 2024 14:28 by avs5190

  • Updated Creator Erica Francis

    March 04, 2024 14:28 by avs5190

  • Updated Creator Eric Schaefer

    March 04, 2024 14:28 by avs5190

  • Updated Creator Chelsea M. Bufalini

    March 04, 2024 14:28 by avs5190

  • Updated Creator Nikole Johnston

    March 04, 2024 14:28 by avs5190

  • Updated Creator Ellie Hogentogler

    March 04, 2024 14:28 by avs5190

  • Updated Creator Jennifer L. Kraschnewski

    March 04, 2024 14:28 by avs5190

  • Updated

    April 04, 2024 10:22 by [unknown user]