Fc Receptor of the Neonate (FcRn): The driver and protector of colostrogenesis

Colostrogenesis is a separate and unique phase of mammary epithelial cell activity occurring in the weeks before parturition and rather abruptly ending after birth in the bovine. It has been the focus of research to define what controls this process and how it produces high concentrations of specific biologically active components important for the neonate. In this review we consider colostrum composition and focus upon components that appear in first milked colostrum in concentrations exceeding that in blood serum. The Fc Receptor of the Neonate (FcRn) is recognized as the major immunoglobulin G (IgG) and albumin binding protein that accounts for the proteins’ long half-lives. We integrate the action of the pinocytotic (fluid phase) uptake of extracellular components and merge them with FcRn in sorting endosomes. We define and explore the means of binding, sorting, and the transcytotic delivery of IgG1 while recycling IgG2 and albumin. We consider the means of releasing the ligands from the receptor within the endosome and describe a new secretion mechanism of cargo release into colostrum without the appearance of FcRn itself in colostrum. We integrate the insulin-like growth factor family, some of which are highly concentrated bioactive components of colostrum, with the mechanisms related to FcRn endosome action. In addition to secretion, we highlight the recent findings of a role of the FcRn in phagocytosis and antigen presentation and relate its significant and abrupt change in cellular location after parturition to a role in the prevention and resistance to mastitis infections.

This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s10911-021-09506-2

Files

Metadata

Work Title Fc Receptor of the Neonate (FcRn): The driver and protector of colostrogenesis
Access
Open Access
Creators
  1. Craig R. Baumrucker
  2. Ann L. Macrina
  3. Rupert M. Bruckmaier
Keyword
  1. Fc receptor of the neonate (FcRn)
  2. Transcytosis Colostrogenesis Endosomal
  3. IGF
  4. Lactoferrin Immunoglobulin
License In Copyright (Rights Reserved)
Work Type Article
Publisher
  1. Journal of Mammary Gland Biology and Neoplasia
Publication Date January 26, 2022
Publisher Identifier (DOI)
  1. https://doi.org/10.1007/s10911-021-09506-2
Deposited August 03, 2022

Versions

Analytics

Collections

This resource is currently not in any collection.

Work History

Version 1
published

  • Created
  • Added Baumrucker_Macrina_Bruckmaier_revision_submitted.docx
  • Added Creator C R Baumrucker
  • Added Creator Ann L Macrina
  • Added Creator Rupert M Bruckmaier
  • Published
  • Updated Work Title, Keyword Show Changes
    Work Title
    • Fc Receptor of the Neonate (FcRn): The driver and protector of colostrogenesis
    • ! Fc Receptor of the Neonate (FcRn): The driver and protector of colostrogenesis
    Keyword
    • Fc receptor of the neonate (FcRn), Transcytosis Colostrogenesis Endosomal , IGF, Lactoferrin Immunoglobulin
  • Renamed Creator Craig R. Baumrucker Show Changes
    • C R Baumrucker
    • Craig R. Baumrucker
  • Renamed Creator Ann L. Macrina Show Changes
    • Ann L Macrina
    • Ann L. Macrina
  • Renamed Creator Rupert M. Bruckmaier Show Changes
    • Rupert M Bruckmaier
    • Rupert M. Bruckmaier
  • Updated Work Title Show Changes
    Work Title
    • ! Fc Receptor of the Neonate (FcRn): The driver and protector of colostrogenesis
    • Fc Receptor of the Neonate (FcRn): The driver and protector of colostrogenesis
  • Updated