Prevalence of Obstructive Hypertrophic Cardiomyopathy in the United States: A MarketScan Claims Analysis
Background: Obstructive hypertrophic cardiomyopathy (oHCM) is the most common genetic heart disease in the US, with an estimated prevalence of 1 in 500. However, the extent to which oHCM is clinically recognized is not well established. Our objective was to estimate the annual prevalence of clinically diagnosed oHCM in the US from 2016 to 2018. Methods: Data from the MarketScan® Commercial Claims and Encounters database, a clinically rich database of longitudinal medical and pharmacy claims data covering over 28 million individuals in the US per year, were queried from years 2016 to 2018 to identify patients with 1 claim of oHCM (International Statistical Classification of Disease and Related Health Problems diagnosis code: I42.1). Prevalence rates for oHCM were calculated and stratified by sex and age. Results: In 2016, 4,612 unique patients had clinical diagnosis of oHCM, resulting in an estimated oHCM prevalence of 1.65 per 10,000. The prevalence of oHCM in males and females was 2.07 and 1.26, respectively. Prevalence of oHCM was highest in patients 55-64 years of age (4.82). Prevalence of oHCM generally increased with age, from 0.36 per 10,000 in those under 18 to 4.82 per 10,000 in those 55-65. Trends in prevalence of oHCM over time, including by sex and age group, remained similar and consistent in 2017 and 2018. Conclusion: The prevalence of oHCM was stable over the 3-year time period, including higher rates of oHCM in males and patients aged 55–64 years. These results suggest that the majority of privately insured patients with oHCM are undiagnosed in the US and reinforce the need for policies and research to improve the clinical identification of oHCM patients in the US.
|Work Title||Prevalence of Obstructive Hypertrophic Cardiomyopathy in the United States: A MarketScan Claims Analysis|
|License||In Copyright (Rights Reserved)|
|Deposited||March 25, 2021|
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