
HCMV infection downregulates GPX4 and stimulates lipid peroxidation but does not induce ferroptosis Figure S1
RSL3 off-target effect on TXNRD does not affect viral replication. (A) Infectious titers at 120 hpi from TB40/E-WT (MOI=3) infected MRC-5 cells treated with vehicle control (DMSO), RSL3 (1M), or Tri-1 (1M) at 72 hpi. Results are from 2 independent experiments, n=6. (B) TXNRD activity (in nmol/min/mL) in MRC-5 cells infected with TB40/E-WT (MOI=3) and treated with DMSO, RSL3 (1M), or Tri-1 (1M) at 72 hpi and harvested at 120hpi. Results are from 1 independent experiment, n=3. For the above panels, * indicates p<0.05, and ns = not significant.
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Work Title | HCMV infection downregulates GPX4 and stimulates lipid peroxidation but does not induce ferroptosis Figure S1 |
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License | CC BY 4.0 (Attribution) |
Work Type | Dataset |
Publication Date | December 20, 2024 |
Deposited | December 20, 2024 |