Perceived stress is linked to heightened biomarkers of inflammation via diurnal cortisol in a national sample of adults

Exposure to and perceptions of stress have been associated with altered systemic inflammation, but the intermediate processes by which stress links to inflammation are not fully understood. Diurnal cortisol slopes were examined as a pathway by which self-reported psychosocial stress is associated with inflammation [i.e., C-reactive protein (CRP), interleukin-6 (IL-6), fibrinogen, E-Selectin, and Intercellular Adhesion Molecule-1 (ICAM-1)] in a large sample of adults (the Midlife in the US study; N = 914; 55.9% female; aged 34–84 years). Structural equation modeling indicated that perceived psychological stress was associated with flattened diurnal cortisol slopes and flatter diurnal cortisol slopes were, in turn, associated with heightened inflammation in these cross-sectional analyses (index of indirect pathway, ω = 0.003, 95% CI [0.001, 0.004], ωSTD = 0.027; with covariates, ω = 0.001, [0.0002, 0.002], ωSTD = 0.011). A similar indirect effect was evident for self-reported traumatic life events (ω = 0.007, [0.004, 0.012], ωSTD = 0.030); however, inclusion of covariates (i.e., age, gender, race, ethnicity, body mass index, and other factors associated with physical health) accounted for this finding (ω = 0.001, [−0.001, 0.004], ωSTD = 0.005). These results support an allostatic load model of psychosomatic health, in which cortisol (along with other stress-responsive signaling molecules) is a necessary component for understanding links between stress exposure, perceived stress, and immune functioning.



Work Title Perceived stress is linked to heightened biomarkers of inflammation via diurnal cortisol in a national sample of adults
Open Access
  1. Erik L. Knight
  2. Yanping Jiang
  3. Jacqueline Rodriguez-Stanley
  4. David M. Almeida
  5. Christopher G. Engeland
  6. Samuele Zilioli
License In Copyright (Rights Reserved)
Work Type Article
  1. Brain, Behavior, and Immunity
Publication Date March 1, 2021
Publisher Identifier (DOI)
Deposited December 08, 2021




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Work History

Version 1

  • Created
  • Added MIDUS_Cortisol_-_Final_-_PSU.docx
  • Added Creator Erik L. Knight
  • Added Creator Yanping Jiang
  • Added Creator Jacqueline Rodriguez-Stanley
  • Added Creator David M. Almeida
  • Added Creator Christopher G. Engeland
  • Added Creator Samuele Zilioli
  • Published
  • Updated
  • Updated
  • Updated