The Effects of Propofol on Left Ventricular Global Longitudinal Strain

Objectives: To determine if hemodynamic changes secondary to propofol administration are a result of direct myocardial depression as measured by global longitudinal strain (GLS). The authors hypothesized that propofol would cause a significant worsening in GLS, indicating direct myocardial depression. Design: Prospective, observational. Setting: Endoscopy suite at a single academic medical center. Participants: Patients undergoing outpatient, elective endoscopic procedures at an outpatient clinic of a single tertiary care academic medical center. Interventions: None. Measurements and Main Results: Limited transthoracic echocardiograms were performed before and after patients received propofol for endoscopic procedures. Post-processing measurements included GLS, 2D (dimensional) ejection fraction (2D EF), and 3D EF. Using paired sample Student’s t test, no statistically significant change in GLS, 2D EF, or 3D EF was found despite statistically significant hypotension. In fact, there was a trend toward more negative GLS (improved myocardial function) in patients after receiving propofol. Conclusion: We found propofol did not cause a reduction in systolic function as measured by GLS, a sensitive measure of myocardial contractility. Therefore, decreases in blood pressure after a propofol bolus in spontaneously breathing patients are likely due to decreased vascular tone and not impaired left ventricular systolic function. These results should be considered in the management of propofol-induced hypotension for spontaneously breathing patients.

Scott R. Coleman et al, The Effects of Propofol on Left Ventricular Global Longitudinal Strain, Seminars in Cardiothoracic and Vascular Anesthesia (25, 3) pp. . Copyright © 2021. DOI: 10.1177/1089253221991372. Users who receive access to an article through a repository are reminded that the article is protected by copyright and reuse is restricted to non-commercial and no derivative uses. Users may also download and save a local copy of an article accessed in an institutional repository for the user's personal reference. For permission to reuse an article, please follow our Process for Requesting Permission.



Work Title The Effects of Propofol on Left Ventricular Global Longitudinal Strain
Open Access
  1. Scott R. Coleman
  2. Theodore J. Cios
  3. Steven Riela
  4. S. Michael Roberts
License In Copyright (Rights Reserved)
Work Type Article
  1. Seminars in Cardiothoracic and Vascular Anesthesia
Publication Date September 1, 2021
Publisher Identifier (DOI)
Deposited February 28, 2023




This resource is currently not in any collection.

Work History

Version 1

  • Created
  • Added The_Effects_of_Propofol_on_Left_Ventricular_Global_Longitudinal_Strain.docx
  • Added Creator Scott R. Coleman
  • Added Creator Theodore J. Cios
  • Added Creator Steven Riela
  • Added Creator S. Michael Roberts
  • Published