Dissolution and In vitro Wound Healing Performance of Chemically Aided Milled Bioactive Glass
In this study, bioactive glass compositions 45S5 and 13-93B3 were processed using attrition milling to produce nanoparticles. Static dissolution and in vitro testing were employed to determine the effect of size and composition on release of therapeutic ions, cell growth, migration. Attrition milling produced a mean particles size below 300 nanometers for both compositions after 2 hours of milling. Static dissolution determined that boron has a lower activation barrier for dissolution than silicon. Cell proliferation using an MTS assay shows that bioactive glass treatments do not stimulate proliferation but can cause cell death if pH rises above the healthy range. A in vitro scratch test was applied to determine the effect of composition and particle size on cell migration. Both 45S5 and 13-93B3 show increased migration rates over no treatment. After 24 hours, 13-93B3 induces 60% wound closure, 45S5 shows 45% and no treatment shows 26%.
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| Work Title | Dissolution and In vitro Wound Healing Performance of Chemically Aided Milled Bioactive Glass |
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| License | No Copyright - U.S. |
| Work Type | Research Paper |
| Publication Date | July 2022 |
| Deposited | October 10, 2023 |