Trajectories of Insomnia Symptoms From Childhood Through Young Adulthood

OBJECTIVES: Insomnia symptoms are transdiagnostic to physical and mental health disorders. Given the lack of population-based cohorts with objective sleep measures and long-term follow-ups, little is known about the chronicity of childhood insomnia symptoms. We determined the developmental trajectories of insomnia symptoms, their evolution into adult insomnia, and the role of objective sleep duration in the transition to adulthood. METHODS: A total of 502 children (median 9 years old, 71.7% response rate) were studied 7.4 years later as adolescents (median 16 years old) and 15 years later as adults (median 24 years old). Insomnia symptoms were ascertained as moderate-to-severe difficulties initiating and/or maintaining sleep via parent- or self reports at all 3 time points, adult insomnia via self-report in young adulthood, and objective short-sleep duration via polysomnography in childhood and adolescence. RESULTS: Among children with insomnia symptoms, the most frequent trajectory was persistence (43.3%), followed by remission (26.9% since childhood, 11.2% since adolescence) and a waxing-and-waning pattern (18.6%). Among children with normal sleep, the most frequent trajectory was persistence (48.1%), followed by developing insomnia symptoms (15.2% since adolescence, 20.7% in adulthood) and a waxing-and-waning pattern (16.0%). The odds of insomnia symptoms worsening into adult insomnia (22.0% of children, 20.8% of adolescents) were 2.6-fold and 5.5-fold among short-sleeping children and adolescents, respectively. CONCLUSIONS: Early sleep interventions are a health priority because pediatricians should not expect insomnia symptoms to developmentally remit in a high proportion of children. Objective sleep measures may be clinically useful in adolescence, a critical period for the adverse prognosis of the insomnia with short-sleep duration phenotype.

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Work Title Trajectories of Insomnia Symptoms From Childhood Through Young Adulthood
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Open Access
Creators
  1. Julio Fernandez-Mendoza
  2. Kristina P. Lenker
  3. Susan L. Calhoun
  4. Myra Qureshi
  5. Anna Ricci
  6. Elizaveta Bourchtein
  7. Fan He
  8. Alexandros N. Vgontzas
  9. Jiangang Liao
  10. Duanping Liao
  11. Edward O. Bixler
Keyword
  1. Adolescent Health/Medicine
  2. Epidemiology
  3. Sleep Medicine
  4. Insomnia
  5. Sleep
  6. Third Heart Sound
License CC BY-NC-ND 4.0 (Attribution-NonCommercial-NoDerivatives)
Work Type Article
Publisher
  1. Pediatrics
Publication Date February 17, 2022
Publisher Identifier (DOI)
  1. https://doi.org/10.1542/peds.2021-053616
Deposited June 18, 2025

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Version 1
published

  • Created
  • Added peds_2021053616-1.pdf
  • Added Creator Julio Fernandez-Mendoza
  • Added Creator Kristina P. Lenker
  • Added Creator Susan L. Calhoun
  • Added Creator Myra Qureshi
  • Added Creator Anna Ricci
  • Added Creator Elizaveta Bourchtein
  • Added Creator Fan He
  • Added Creator Alexandros N. Vgontzas
  • Added Creator Jiangang Liao
  • Added Creator Duanping Liao
  • Added Creator Edward O. Bixler
  • Published
  • Updated
  • Updated Keyword, Publication Date Show Changes
    Keyword
    • Adolescent Health/Medicine , Epidemiology , Sleep Medicine , Insomnia, Sleep , Third Heart Sound
    Publication Date
    • 2022-03-01
    • 2022-02-17