-
Created
July 26, 2022 11:21
by
Researcher Metadata Database
-
Added
SWA_and_Disorders_Paper_SleepMed_R1_Clean.docx
July 26, 2022 11:21
by
Researcher Metadata Database
-
Added
SWA_and_Disorders_Supplement_SleepMed_R1.docx
July 26, 2022 11:21
by
Researcher Metadata Database
-
Added
SWA_and_Disorders_Highlights_SleepMed_R1.docx
July 26, 2022 11:21
by
Researcher Metadata Database
-
Added
Figure_1._Cross-sectional.pdf
July 26, 2022 11:21
by
Researcher Metadata Database
-
Added Creator Anna Ricci
July 26, 2022 11:21
by
Researcher Metadata Database
-
Added Creator Fan He
July 26, 2022 11:21
by
Researcher Metadata Database
-
Added Creator Susan L. Calhoun
July 26, 2022 11:21
by
Researcher Metadata Database
-
Added Creator Jidong Fang
July 26, 2022 11:21
by
Researcher Metadata Database
-
Added Creator Alexandros N. Vgontzas
July 26, 2022 11:21
by
Researcher Metadata Database
-
Added Creator Duanping Liao
July 26, 2022 11:21
by
Researcher Metadata Database
-
Added Creator Edward O. Bixler
July 26, 2022 11:21
by
Researcher Metadata Database
-
Added Creator Julio Fernandez-Mendoza
July 26, 2022 11:21
by
Researcher Metadata Database
-
Published
July 26, 2022 11:21
by
Researcher Metadata Database
-
September 09, 2022 10:25
by
pmk5516
Work Title
Evidence of a maturational disruption in non-rapid eye movement sleep slow wave activity in youth with attention-deficit/hyperactivity, learning and internalizing disorders
- ! Evidence of a maturational disruption in non-rapid eye movement sleep slow wave activity in youth with attention-deficit/hyperactivity, learning and internalizing disorders
Keyword
- ADHD, adolescents, children, internalizing disorder, slow wave activity, sleep depth
Description
<p>Background: Sleep slow wave activity (SWA) peaks during childhood and declines in the transition to adolescence during typical development (TD). It remains unknown whether this trajectory differs in youth with neuropsychiatric disorders. Methods: We analyzed sleep EEGs of 664 subjects 6 to 21 y (449 TD, 123 unmedicated, 92 medicated) and 114 subjects 7-12 y (median 10.5 y) followed-up at 18-22 y (median 19 y). SWA (0.4–4 Hz) power was calculated during non-rapid eye movement sleep. Results: TD and unmedicated youth showed cubic central and frontal SWA trajectories from 6 to 21 y (p-cubic<0.05), with TD youth showing peaks in central SWA at 6.8 y and frontal at 8.2 y. Unmedicated attention-deficit/hyperactivity (ADHD) and/or learning disorders (LD) showed peak central SWA 2 y later (at 9.6 y, coinciding with peak frontal SWA) than TD, followed by a 67% steeper slope by 19 y. Frontal SWA peak and slope in unmedicated ADHD/LD, and that of central and frontal in internalizing disorders (ID), were similar to TD. Unmedicated ADHD/LD did not differ in the longitudinal SWA percent change by 18–22 y; unmedicated ID showed a lower longitudinal change in frontal SWA than TD. Medicated youth showed a linear decline in central and frontal SWA from 6 to 21 y (p-linear<0.05). Conclusions: ADHD/LD youth show a maturational delay and potential topographical disruption in SWA during childhood and steeper decline throughout adolescence, suggesting faster synaptic pruning. Youth with ID experience less changes in frontal SWA by late adolescence. Psychotropic medications may impact the maturational trajectory of SWA, but not the magnitude of developmental decline by late adolescence.</p>
- Background: Sleep slow wave activity (SWA) peaks during childhood and declines in the transition to adolescence during typical development (TD). It remains unknown whether this trajectory differs in youth with neuropsychiatric disorders. Methods: We analyzed sleep EEGs of 664 subjects 6 to 21 y (449 TD, 123 unmedicated, 92 medicated) and 114 subjects 7-12 y (median 10.5 y) followed-up at 18-22 y (median 19 y). SWA (0.4–4 Hz) power was calculated during non-rapid eye movement sleep. Results: TD and unmedicated youth showed cubic central and frontal SWA trajectories from 6 to 21 y (p-cubic<0.05), with TD youth showing peaks in central SWA at 6.8 y and frontal at 8.2 y. Unmedicated attention-deficit/hyperactivity (ADHD) and/or learning disorders (LD) showed peak central SWA 2 y later (at 9.6 y, coinciding with peak frontal SWA) than TD, followed by a 67% steeper slope by 19 y. Frontal SWA peak and slope in unmedicated ADHD/LD, and that of central and frontal in internalizing disorders (ID), were similar to TD. Unmedicated ADHD/LD did not differ in the longitudinal SWA percent change by 18–22 y; unmedicated ID showed a lower longitudinal change in frontal SWA than TD. Medicated youth showed a linear decline in central and frontal SWA from 6 to 21 y (p-linear<0.05). Conclusions: ADHD/LD youth show a maturational delay and potential topographical disruption in SWA during childhood and steeper decline throughout adolescence, suggesting faster synaptic pruning. Youth with ID experience less changes in frontal SWA by late adolescence. Psychotropic medications may impact the maturational trajectory of SWA, but not the magnitude of developmental decline by late adolescence.
-
May 24, 2023 14:02
by
pmk5516
Work Title
! Evidence of a maturational disruption in non-rapid eye movement sleep slow wave activity in youth with attention-deficit/hyperactivity, learning and internalizing disorders
- Evidence of a maturational disruption in non-rapid eye movement sleep slow wave activity in youth with attention-deficit/hyperactivity, learning and internalizing disorders
-
Updated
April 04, 2024 10:21
by
[unknown user]