Assessing nonsexual transmission of the human papillomavirus (HPV): Do our current cleaning methods work?

Human papillomavirus (HPV) is thought to be sexually transmitted; however, there have been a few studies investigating a possible iatrogenic source of infection. Therefore, it is important to assess the cleaning methods of reusable medical devices. This study assessed whether cleaning methods of flexible endoscopes in an otolaryngology clinic are effective against HPV. There were 24 patients with a history of head and neck cancer in the study; however, two outliers were excluded. Nine patients were confirmed to have HPV-associated cancer. PCR was used to measure and quantify the viral genomes of samples collected before and after cleaning. After cleaning, few HPV+ samples had endoscopes with less DNA than before cleaning. Additionally, for several patients with non-HPV-associated head and neck cancer, PCR showed more DNA after cleaning than before cleaning, suggesting residual HPV DNA within the cleaning solution. There was no significant difference (p > 0.05) between pre- and post-cleaning in both cohorts. Current cleaning methods of reusable endoscopes may not be effective in completely removing viral DNA.

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Work Title Assessing nonsexual transmission of the human papillomavirus (HPV): Do our current cleaning methods work?
Access
Open Access
Creators
  1. J Tucker
  2. J Milici
  3. Samina Alam
  4. Ashley P.O.Connell Ferster
  5. David Goldenberg
  6. Craig Meyers
  7. Neerav Goyal
Keyword
  1. human papillomavirus
  2. infection
  3. oncogenesis
  4. sexually transmitted disease
License In Copyright (Rights Reserved)
Work Type Article
Publisher
  1. Journal of Medical Virology
Publication Date April 8, 2022
Publisher Identifier (DOI)
  1. https://doi.org/10.1002/jmv.27769
Deposited November 08, 2024

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Version 1
published

  • Created
  • Added nonsexual-transmission-hpv.pdf
  • Added Creator J Tucker
  • Added Creator J Milici
  • Added Creator Samina Alam
  • Added Creator Ashley P.O.Connell Ferster
  • Added Creator Ferster APO
  • Added Creator David Goldenberg
  • Added Creator Craig Meyers
  • Added Creator Neerav Goyal
  • Published
  • Updated
  • Updated Keyword, Publication Date Show Changes
    Keyword
    • human papillomavirus , infection, oncogenesis , sexually transmitted disease
    Publication Date
    • 2022-01-01
    • 2022-04-08
  • Deleted Creator Ferster APO
  • Updated Creator David Goldenberg
  • Updated Creator Craig Meyers
  • Updated Creator Neerav Goyal