Development of GC/MS Categorization Methodology for Benzodiazepines

The development of standardized gas chromatographic analysis for benzodiazepine structures aids in the essential understanding of chemical behaviors and variabilities associated with the group and potential mixtures. This study aims to optimize gas chromatography-mass spectrometry conditions and enhance the detection and quantification of compounds within a panel of benzodiazepines. Both Full Scan and Select Ion Monitoring (SIM) acquisition modes were used for compound analysis. Full Scan Mode offered superior detection rate and identification consistency while SIM developed the foundation for limited subcategorization of benzodiazepines. The finalized method demonstrates the foundation of an effective separation method. The GC-MS methodology aids in the creation of a reliable analytical approach for future forensic and pharmaceutical applications.

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Work Title Development of GC/MS Categorization Methodology for Benzodiazepines
Subtitle Scientific Research Distinction Thesis (SCIRES)
Access
Open Access
Creators
  1. Alecia Smith-McLean
Keyword
  1. SCIRES
  2. Diazepam
  3. GC/MS
  4. Flunitrazepam
License In Copyright (Rights Reserved)
Work Type Research Paper
Acknowledgments
  1. Dr. William Campbell
Publication Date May 2, 2025
Deposited May 02, 2025

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Version 1
published

  • Created

    May 02, 2025 11:32 by afs6586

  • Updated

    May 02, 2025 11:32 by [unknown user]

  • Updated Keyword, Subtitle, Description, and 1 more Show Changes

    May 02, 2025 11:39 by afs6586

    Keyword
    • SCIRES, Diazepam, GC/MS, Flunitrazepam
    Subtitle
    • Scientific Research Distinction Thesis (SCIRES)
    Description
    • The development of standardized gas chromatographic analysis for benzodiazepine structures aids in the essential understanding of chemical behaviors and variabilities associated with the group and potential mixtures. This study aims to optimize gas chromatography-mass spectrometry conditions and enhance the detection and quantification of compounds within a panel of benzodiazepines. Both Full Scan and Select Ion Monitoring (SIM) acquisition modes were used for compound analysis. Full Scan Mode offered superior detection rate and identification consistency while SIM developed the foundation for limited subcategorization of benzodiazepines. The finalized method demonstrates the foundation of an effective separation method. The GC-MS methodology aids in the creation of a reliable analytical approach for future forensic and pharmaceutical applications.
    Publication Date
    • 2025-05-02
  • Updated Acknowledgments Show Changes

    May 02, 2025 11:40 by afs6586

    Acknowledgments
    • Dr. William Campbell
  • Added Creator Alecia Smith-McLean

    May 02, 2025 11:40 by afs6586

  • Added MS Categorization Methodology for Benzodiazepines.pdf

    May 02, 2025 11:40 by afs6586

  • Updated License Show Changes

    May 02, 2025 11:44 by afs6586

    License
    • https://rightsstatements.org/page/InC/1.0/
  • Published

    May 02, 2025 13:10 by afs6586

  • Updated

    May 02, 2025 22:05 by [unknown user]