Incidence of Post Liver Transplantation Hepatic Dysfunction after Sustained Virological Response Following Direct Acting Anti-Hepatitis C Therapy

Objectives: Newly developed, direct-acting antiviral therapy is effective in over 90% of cases to eradicate hepatitis C virus infection. Direct-acting antiviral therapy is also effective in liver transplant recipients with recurrent hepatitis C virus infection. However, hepatic function after sustained virologic response in transplant recipients is unknown. Here, we aimed to uncover the incidence of hepatic dysfunction in this patient group at our center.

Materials and methods: Our study included 40 consecutive (January 2014 to February 2016) and compliant posttransplant recipients who achieved sustained viral response from direct-acting antiviral therapy. Patients were investigated for incidence and causes of hepatic dysfunction.

Results: In our patient group, 4 (10%) experienced hepatic dysfunction with stable baseline immunosuppression, with 2 having drastic increases in alanine aminotransferase at 15 and 32 weeks after direct-acting antiviral therapy. Biopsies showed hepatitis, and both patients were treated with hydrocortisone, which increased their baseline immunosuppression. The 3rd patient had an increase in bilirubin at 21 weeks posttherapy, with biopsy showing macrovascular steatosis. The 4th patient had a rapid increase in bilirubin at 7 weeks after direct-acting antiviral therapy, with biopsy showing significant duct loss.

Conclusions: During the study period, 10% of patients experienced hepatic dysfunction after sustained viral response. Presumed causative factors included partial immune reconstitution and nonalcoholic fatty liver disease.

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Work Title Incidence of Post Liver Transplantation Hepatic Dysfunction after Sustained Virological Response Following Direct Acting Anti-Hepatitis C Therapy
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Open Access
Creators
  1. Ashokkumar Jain
  2. Thomas R Riley III
  3. Karen L Krok
  4. Ian Roy Schreibman
  5. Dipti Mahajan Karamchandani
  6. Xiaojie Liao
  7. Ye Tian
  8. Takehiko Dohi
  9. Zakiyah Kadry
Keyword
  1. Chronic rejection
  2. Immune system recon­stitution
  3. Immunosuppression
  4. Nonalcoholic fatty liver disease
License In Copyright (Rights Reserved)
Work Type Article
Publisher
  1. Experimental and Clinical Transplantation
Publication Date June 2020
Publisher Identifier (DOI)
  1. 10.6002/ect.2018.0127
Related URLs
Deposited August 23, 2021

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Version 1
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  • Created
  • Added Creator Ashokkumar Jain
  • Added Creator Thomas R Riley III
  • Added Creator Karen L Krok
  • Added Creator Ian Roy Schreibman
  • Added Creator Dipti Mahajan Karamchandani
  • Added Creator Xiaojie Liao
  • Added Creator Ye Tian
  • Added Creator Takehiko Dohi
  • Added Creator Zakiyah Kadry
  • Added DAA_first_Exper_cli_trans__proof_hi-1_04_11_18.pdf
  • Updated License Show Changes
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    • https://rightsstatements.org/page/InC/1.0/
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