MRI-Compatible, Transparent PEDOT:PSS Neural Implants for the Alleviation of Neuropathic Pain with Motor Cortex Stimulation

Simultaneous monitoring of electrophysiology and magnetic resonance imaging (MRI) could guide the innovative diagnosis and treatment of various neurodegenerative diseases that are previously impossible. However, this technique is difficult because the existing metal-based implantable neural interface for electrophysiology is not free from signal distortions from its intrinsic magnetic susceptibility while performing an MRI of the implanted area of the neural interface. Moreover, brain tissue heating from neural implants generated by the radiofrequency field from MRI poses potential hazards for patients. Previous studies with soft polymer-based electrode arrays provide relatively suitable MRI compatibility but does not guarantee high-resolution electrophysiological signal acquisition and stimulation performance. Here, MRI compatible, optically transparent flexible implantable device capable of electrophysiological multichannel mapping and electrical stimulation is introduced. Using the device, neuropathic pain (NP) relief with a 30-channel electrophysiological mapping of the somatosensory area before and after motor cortex stimulation (MCS) in allodynia rats after noxious stimulation is confirmed. Additionally, artifact-free manganese-enhanced MRI of dramatic relief of pain-related region activity by MCS is demonstrated. Furthermore, artifact-free optogenetics with transgenic mice is also investigated by recording light-evoked potentials. These results suggest a promising neuro-prosthetic for analyzing and modulating spatiotemporal neurodynamic without MRI or optical modality resolution constraints.

This is the peer reviewed version of the following article: [MRI‐Compatible, Transparent PEDOT:PSS Neural Implants for the Alleviation of Neuropathic Pain with Motor Cortex Stimulation. Advanced Functional Materials (2023)], which has been published in final form at https://doi.org/10.1002/adfm.202310908. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions: https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/self-archiving.html#3.

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Work Title MRI-Compatible, Transparent PEDOT:PSS Neural Implants for the Alleviation of Neuropathic Pain with Motor Cortex Stimulation
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Open Access
Creators
  1. Young Uk Cho
  2. Kyeongmin Kim
  3. Ankan Dutta
  4. Sang Hoon Park
  5. Ju Young Lee
  6. Hyun Woo Kim
  7. Jieon Park
  8. Jiwon Kim
  9. Won Kyung Min
  10. Chihyeong Won
  11. Jaejin Park
  12. Yujin Kim
  13. Jong Youl Kim
  14. Taeyoon Lee
  15. Hyun Jae Kim
  16. Donghyun Kim
  17. Jong Eun Lee
  18. Byung Wook Min
  19. Il Joo Cho
  20. Bae Hwan Lee
  21. Huanyu Cheng
  22. Myeounghoon Cha
  23. Ki Jun Yu
Keyword
  1. MRI compatible neural implant
  2. PEDOT:PSS
  3. Transparent electrode
  4. Neuropathic pain alleviation
License In Copyright (Rights Reserved)
Work Type Article
Publisher
  1. Advanced Functional Materials
Publication Date October 27, 2023
Publisher Identifier (DOI)
  1. https://doi.org/10.1002/adfm.202310908
Deposited January 29, 2024

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Version 1
published

  • Created
  • Added revised_manuscript_non_highlighted.docx
  • Added Creator Young Uk Cho
  • Added Creator Kyeongmin Kim
  • Added Creator Ankan Dutta
  • Added Creator Sang Hoon Park
  • Added Creator Ju Young Lee
  • Added Creator Hyun Woo Kim
  • Added Creator Jieon Park
  • Added Creator Jiwon Kim
  • Added Creator Won Kyung Min
  • Added Creator Chihyeong Won
  • Added Creator Jaejin Park
  • Added Creator Yujin Kim
  • Added Creator Jong Youl Kim
  • Added Creator Taeyoon Lee
  • Added Creator Hyun Jae Kim
  • Added Creator Donghyun Kim
  • Added Creator Jong Eun Lee
  • Added Creator Byung Wook Min
  • Added Creator Il Joo Cho
  • Added Creator Bae Hwan Lee
  • Added Creator Huanyu Cheng
  • Added Creator Myeounghoon Cha
  • Added Creator Ki Jun Yu
  • Published
  • Updated Keyword, Publication Date Show Changes
    Keyword
    • MRI compatible neural implant, PEDOT:PSS, Transparent electrode, Neuropathic pain alleviation
    Publication Date
    • 2023-01-01
    • 2023-10-27
  • Added Supporting information.pdf
  • Updated