DEF1

Degradation Factor 1 was discovered 20 years ago as a yeast protein copurifying with Rad26, a helicase involved in transcription-coupled DNA repair. It was subsequently shown to control the ubiquitylation and destruction of the large subunit of DNA damage-arrested RNA Polymerase II. Since that time, much has been learned about Def1′s role in polymerase destruction and new functions of the protein have been revealed. We now understand that Def1 is involved in more than just RNA polymerase II regulation. Most of its known functions are associated with maintaining chromosome and genomic integrity, but other exciting activities outside this realm have been suggested. Here we review this fascinating protein, describe its regulation and present a hypothesis that Def1 is a central coordinator of ubiquitin signaling pathways in cells.

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Work Title DEF1
Subtitle Much more than an RNA polymerase degradation factor
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Open Access
Creators
  1. Oluwasegun T. Akinniyi
  2. Joseph C. Reese
License In Copyright (Rights Reserved)
Work Type Article
Publisher
  1. DNA Repair
Publication Date November 1, 2021
Publisher Identifier (DOI)
  1. https://doi.org/10.1016/j.dnarep.2021.103202
Deposited November 15, 2021

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Version 1
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  • Created
  • Added DNA_repair_review.pdf
  • Added Creator Oluwasegun T. Akinniyi
  • Added Creator Joseph C. Reese
  • Published
  • Updated
  • Updated