Genetic associations with consumption of palatable foods in the absence of hunger in response to food cues in children
SummaryObjective: The objective of this study is to evaluate obesity-related genetic factors inrelation to excess consumption and assess if food cues modify associations.Methods: Children (9–12 years) completed a randomized crossover experiment. Dur-ing two visits, children ate a preload and then snacks ad libitum while watching televi-sion, embedded with food or non-food advertisements to assess eating in theabsence of hunger (EAH). Primary exposures were obesity-associated genotypes,FTO rs9939609 and MC4R rs571312, and a paediatric-specific polygenic risk score(PRS). Outcomes included consumption of all snacks (total EAH) and gummy candyonly (gummy candy EAH). Linear mixed-effects models tested whether genetic expo-sures related to EAH outcomes. We tested for effect modification by food cues usingmultiplicative interaction terms.Results: Among 177 children, each FTO risk allele was associated with a 30% increasein gummy candy EAH (p = 0.025) in adjusted models. Food cue exposure exacer-bated associations between the FTO variant with gummy candy EAH (p = 0.046). Nostatistically significant associations were found between MC4R and EAH.Conclusion: The results suggest children with the FTO rs9939609 risk allele may bepredisposed to excess consumption of candy and that this association may be exacer-bated by food cues.
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| Work Title | Genetic associations with consumption of palatable foods in the absence of hunger in response to food cues in children |
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| License | In Copyright (Rights Reserved) |
| Work Type | Article |
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| Publication Date | August 28, 2024 |
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| Deposited | June 09, 2025 |
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