Multiple Sclerosis Heredity in Relation to Mitochondrial Disorders Public

Multiple sclerosis (MS) is a neurodegenerating disease with an unknown inheritance pattern. The dysfunction of the mitochondria within cells of MS patients suggests that it could be a mitochondrial disorder. Linkage to the mitochondria also reveals a possible inheritance pattern: MS could be passed down through mitochondrial DNA (mtDNA), or maternally. Though the disease is multifactorial, research has shown that there are many gene variants which can lead to a genetic predisposition for susceptibility to MS. On a cellular level, the mitochondrial dysfunctions resemble those of other diseases that are passed down through mtDNA, such as Leber’s hereditary optic neuropathy. This evidence infers that it is very likely that MS is a mitochondrial disorder and is inherited maternally. Currently, researchers are exploring the development of mitochondrial-based therapies for MS patients.