Molecular phylogeography of a human autosomal skin color locus under natural selection Public

The A111T mutation in SLC24A5 is unique to european origins. This paper addresses the question of where and when this mutation occurred, using the global distribution of haplotypes in the genomic region around SLC24A5. The mutation arose somewhere in the Middle East after a recombination event between two prior haplotypes that are presently common in the Far East and New World, in time for the repopulation of Europe after the last ice ages that peaked about 15kya.


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