Testing Potential Inhibitors of the Sigma E Pathway in Escherichia Coli Public

The bacterial σE-Pathway is a vital stress response pathway that allows bacteria to survive in conditions that would disrupt the cell envelope. Disrupting this pathway with novel chemical inhibitors may lead to the production of innovate antimicrobial therapeutics. Screening with fluorescence-based assays identified several compounds with potential inhibitory activity. From this, the compounds were characterized for their efficacy and inhibitory profiles against Escherichia Coli.

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